Literature DB >> 8534204

Use of dantrolene in experimental scorpion envenomation by Androctonus australis hector.

R Guieu, C Kopeyan, F Sampieri, C Devaux, G Bechis, H Rochat.   

Abstract

Hyperthermia and profuse perspiration are rarely absent in severe cases of scorpion envenomation. Based on these observations, the aim of this study was to determine the therapeutic effects of dantrolene, on experimental poisoning by the venom of Androctonus australis hector. Dantrolene is a directly acting muscle relaxant which lowers the body temperature in malignant hyperthermia. The results indicate that the early use of this drug raises the LD50 in experimentally poisoned mice. If these results are transposable to humans, dantrolene could be a useful therapeutic adjuvant.

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Year:  1995        PMID： 8534204     DOI： 10.1007/s002040050216

Source DB:  PubMed          Journal:  Arch Toxicol        ISSN： 0340-5761            Impact factor:   5.153


  20 in total

1.  The role of propranolol and atropine in mitigating the toxic effects of scorpion venom on rat electrocardiogram.

Authors:  M A Omran; M S Abdel-Rahman; Z I Nabil
Journal:  Toxicol Lett       Date:  1992-07       Impact factor: 4.372

2.  Vasodilators and calcium blocking agents as treatment of cardiovascular manifestations of human scorpion envenomation.

Authors:  M Gueron; S Sofer
Journal:  Toxicon       Date:  1990       Impact factor: 3.033

3.  Fatal stroke following scorpion bite.

Authors:  S K Tiwari; G B Gupta; S R Gupta; S N Mishra; P K Pradhan
Journal:  J Assoc Physicians India       Date:  1988-03

4.  Localized cerebral involvement caused by a yellow scorpion sting on the face: two case reports.

Authors:  Y Elitsur; J Urbach; J Hershkovich; S Moses
Journal:  Isr J Med Sci       Date:  1984-02

Review 5.  Dantrolene.

Authors:  B A Britt
Journal:  Can Anaesth Soc J       Date:  1984-01

6.  Heat stroke and malignant hyperpyrexia.

Authors:  M A Denborough
Journal:  Med J Aust       Date:  1982-03-06       Impact factor: 7.738

7.  Role of lytic cocktail and atropine in neutralizing scorpion venom effects.

Authors:  B S Gajalakshmi
Journal:  Indian J Med Res       Date:  1978-06       Impact factor: 2.375

8.  Do changes in body temperature following envenomation by the scorpion Leiurus quinquestriatus influence the course of toxicity?

Authors:  M Ismail; M A Abd-Elsalam; A M Morad
Journal:  Toxicon       Date:  1990       Impact factor: 3.033

Review 9.  Dantrolene. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in malignant hyperthermia, the neuroleptic malignant syndrome and an update of its use in muscle spasticity.

Authors:  A Ward; M O Chaffman; E M Sorkin
Journal:  Drugs       Date:  1986-08       Impact factor: 9.546

10.  Vasodilators and hypertensive encephalopathy following scorpion envenomation in children.

Authors:  S Sofer; M Gueron
Journal:  Chest       Date:  1990-01       Impact factor: 9.410
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  1 in total

1.  Neurotoxicity of Tityus bahiensis (brown scorpion) venom in sympathetic vas deferens preparations and neuronal cells.

Authors:  Rita de Cássia Collaço; Stephen Hyslop; Thalita Rocha; Valquiria A C Dorce; Edward G Rowan; Edson Antunes
Journal:  Arch Toxicol       Date:  2020-06-16       Impact factor: 5.153
  1 in total

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