Literature DB >> 8533157

Cellular responses to DNA damage: cell-cycle checkpoints, apoptosis and the roles of p53 and ATM.

T Enoch1, C Norbury.   

Abstract

'Checkpoint' controls arrest the cell cycle after DNA damage, allowing repair to take place before mutations can be perpetuated. In multicellular organisms, DNA damage can also induce apoptotic cell death, protecting the organism at the expense of the individual cell. How does a cell 'choose' between cycle arrest and death? Analysis of two human tumour suppressor proteins, p53 and the ATM (ataxia-telangiectasia mutated) gene product, may provide some answers.

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Year:  1995        PMID： 8533157     DOI： 10.1016/s0968-0004(00)89093-3

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   13.807


  63 in total

1.  The G(2) checkpoint is maintained by redundant pathways.

Authors:  T M Passalaris; J A Benanti; L Gewin; T Kiyono; D A Galloway
Journal:  Mol Cell Biol       Date:  1999-09       Impact factor: 4.272

2.  Repression of CDK1 and other genes with CDE and CHR promoter elements during DNA damage-induced G(2)/M arrest in human cells.

Authors:  C Badie; J E Itzhaki; M J Sullivan; A J Carpenter; A C Porter
Journal:  Mol Cell Biol       Date:  2000-04       Impact factor: 4.272

3.  Comparison of the expression of p53, p21, Bax and the induction of apoptosis between patients with basal cell carcinoma and normal controls in response to ultraviolet irradiation.

Authors:  M Murphy; M J E M F Mabruk; P Lenane; A Liew; P McCann; A Buckley; C O Flatharta; D Hevey; P Billet; W Robertson; S Javed; M Leader; E Kay; G M Murphy
Journal:  J Clin Pathol       Date:  2002-11       Impact factor: 3.411

Review 4.  Oxidative stress in microorganisms--I. Microbial vs. higher cells--damage and defenses in relation to cell aging and death.

Authors:  K Sigler; J Chaloupka; J Brozmanová; N Stadler; M Höfer
Journal:  Folia Microbiol (Praha)       Date:  1999       Impact factor: 2.099

5.  Depletion of Wee-1 kinase is necessary for both human immunodeficiency virus type 1 Vpr- and gamma irradiation-induced apoptosis.

Authors:  Huidong Yuan; Yi-Ming Xie; Irvin S Y Chen
Journal:  J Virol       Date:  2003-02       Impact factor: 5.103

6.  Effect of Helicobacter pylori on gastric epithelial cell migration and proliferation in vitro: role of VacA and CagA.

Authors:  V Ricci; C Ciacci; R Zarrilli; P Sommi; M K Tummuru; C Del Vecchio Blanco; C B Bruni; T L Cover; M J Blaser; M Romano
Journal:  Infect Immun       Date:  1996-07       Impact factor: 3.441

7.  The novel DNA damage checkpoint protein ddc1p is phosphorylated periodically during the cell cycle and in response to DNA damage in budding yeast.

Authors:  M P Longhese; V Paciotti; R Fraschini; R Zaccarini; P Plevani; G Lucchini
Journal:  EMBO J       Date:  1997-09-01       Impact factor: 11.598

8.  Oxidative stress causes relocation of the lysosomal enzyme cathepsin D with ensuing apoptosis in neonatal rat cardiomyocytes.

Authors:  K Roberg; K Ollinger
Journal:  Am J Pathol       Date:  1998-05       Impact factor: 4.307

9.  Immunohistochemical retrieval of the principal HIV antigens p24, gp41, and gp120 in formalin fixed tissue: an investigation using HIV infected lymphoblasts and postmortem brain tissue from AIDS cases.

Authors:  H L Morrison; J W Neal; A B Parkes; B Jasani
Journal:  Mol Pathol       Date:  1998-08

10.  Alcohol exposure alters cell cycle and apoptotic events during early neurulation.

Authors:  Bruce Anthony; Feng C Zhou; Tetsuo Ogawa; Charles R Goodlett; Joseph Ruiz
Journal:  Alcohol Alcohol       Date:  2008-02-18       Impact factor: 2.826
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