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Literature DB >> 8533154

DNA double-strand break repair and V(D)J recombination: involvement of DNA-PK.

Abstract

Two processes involving DNA double-strand breaks (DSBs) are the repair of DNA damage induced by ionizing radiation, and V(D)J recombination, the genomic rearrangement that creates antigen-receptor diversity in vertebrates. Recent evidence indicates that DNA-dependent protein kinase (DNA-PK), which is activated by DNA ends, is a central component of both the DNA DSB repair and V(D)J recombination machineries.

Entities: Disease Gene

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Year: 1995 PMID： 8533154 DOI： 10.1016/s0968-0004(00)89090-8

Source DB: PubMed Journal: Trends Biochem Sci ISSN： 0968-0004 Impact factor: 13.807

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Cited

88 in total

1. The RAG1 homeodomain recruits HMG1 and HMG2 to facilitate recombination signal sequence binding and to enhance the intrinsic DNA-bending activity of RAG1-RAG2.

Authors: V Aidinis; T Bonaldi; M Beltrame; S Santagata; M E Bianchi; E Spanopoulou
Journal: Mol Cell Biol Date: 1999-10 Impact factor: 4.272

2. I-SceI endonuclease, a new tool for studying DNA double-strand break repair mechanisms in Drosophila.

Authors: Y Bellaiche; V Mogila; N Perrimon
Journal: Genetics Date: 1999-07 Impact factor: 4.562

Review 3. Primary T-lymphocyte immunodeficiencies.

Authors: A Fischer
Journal: Clin Rev Allergy Immunol Date: 2001-02 Impact factor: 8.667

4. Ku-dependent nonhomologous DNA end joining in Xenopus egg extracts.

Authors: P Labhart
Journal: Mol Cell Biol Date: 1999-04 Impact factor: 4.272

5. Hyper-resistance of meiotic cells to radiation due to a strong expression of a single recA-like gene in Caenorhabditis elegans.

Authors: T Takanami; A Mori; H Takahashi; A Higashitani
Journal: Nucleic Acids Res Date: 2000-11-01 Impact factor: 16.971

6. DNA double-strand break repair in cell-free extracts from Ku80-deficient cells: implications for Ku serving as an alignment factor in non-homologous DNA end joining.

Authors: E Feldmann; V Schmiemann; W Goedecke; S Reichenberger; P Pfeiffer
Journal: Nucleic Acids Res Date: 2000-07-01 Impact factor: 16.971

DNA double-strand break repair and V(D)J recombination: involvement of DNA-PK.

1. The RAG1 homeodomain recruits HMG1 and HMG2 to facilitate recombination signal sequence binding and to enhance the intrinsic DNA-bending activity of RAG1-RAG2.

2. I-SceI endonuclease, a new tool for studying DNA double-strand break repair mechanisms in Drosophila.

Review 3. Primary T-lymphocyte immunodeficiencies.

4. Ku-dependent nonhomologous DNA end joining in Xenopus egg extracts.

5. Hyper-resistance of meiotic cells to radiation due to a strong expression of a single recA-like gene in Caenorhabditis elegans.

6. DNA double-strand break repair in cell-free extracts from Ku80-deficient cells: implications for Ku serving as an alignment factor in non-homologous DNA end joining.

7. Deficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joining.

8. Capture of DNA sequences at double-strand breaks in mammalian chromosomes.

9. Promiscuous patching of broken chromosomes in mammalian cells with extrachromosomal DNA.

Review 10. Parental origin and timing of de novo Robertsonian translocation formation.