Literature DB >> 8533143

Positive cooperativity among insecticidal scorpion neurotoxins.

R Herrmann1, H Moskowitz, E Zlotkin, B D Hammock.   

Abstract

The insecticidal activity of scorpion neurotoxic polypeptides increased 5-10-fold with no apparent increase in mammalian toxicity when a combination of two toxins was injected. Synergistic combinations could be predicted from binding studies and competitive displacement assays. Our results indicate that simultaneous expression in baculovirus or other transgenic organisms of the synergistic combinations of insecticidal toxins may result in more potent insect-selective biopesticides.

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Year:  1995        PMID: 8533143     DOI: 10.1016/0041-0101(95)98053-x

Source DB:  PubMed          Journal:  Toxicon        ISSN: 0041-0101            Impact factor:   3.033


  3 in total

1.  CSTX-13, a highly synergistically acting two-chain neurotoxic enhancer in the venom of the spider Cupiennius salei (Ctenidae).

Authors:  Benno Wullschleger; Lucia Kuhn-Nentwig; Jan Tromp; Urs Kämpfer; Johann Schaller; Stefan Schürch; Wolfgang Nentwig
Journal:  Proc Natl Acad Sci U S A       Date:  2004-07-22       Impact factor: 11.205

Review 2.  A new approach to insect-pest control--combination of neurotoxins interacting with voltage sensitive sodium channels to increase selectivity and specificity.

Authors:  D Gordon
Journal:  Invert Neurosci       Date:  1997 Sep-Dec

3.  Optimized scorpion polypeptide LMX: a pest control protein effective against rice leaf folder.

Authors:  Xiuzi Tianpei; Yingguo Zhu; Shaoqing Li
Journal:  PLoS One       Date:  2014-06-25       Impact factor: 3.240

  3 in total

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