Literature DB >> 8533092

A subclass of bHLH proteins required for cardiac morphogenesis.

D Srivastava1, P Cserjesi, E N Olson.   

Abstract

Skeletal muscle development is controlled by a family of muscle-specific basic helix-loop-helix (bHLH) transcription factors. Two bHLH genes, dHAND and eHAND, have now been isolated that are expressed in the bilateral heart primordia and subsequently throughout the primitive tubular heart and its derivatives during chick and mouse embryogenesis. Incubation of stage 8 chick embryos with dHAND and eHAND antisense oligonucleotides revealed that either oligonucleotide alone had no effect on embryonic development, whereas together they arrested development at the looping heart tube stage. Thus, dHAND and eHAND may play redundant roles in the regulation of the morphogenetic events of vertebrate heart development.

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Year:  1995        PMID： 8533092     DOI： 10.1126/science.270.5244.1995

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  110 in total

Review 1.  The basic helix-loop-helix transcription factor, dHAND, is required for vascular development.

Authors:  H Yamagishi; E N Olson; D Srivastava
Journal:  J Clin Invest       Date:  2000-02       Impact factor: 14.808

Review 2.  Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms.

Authors:  M E Massari; C Murre
Journal:  Mol Cell Biol       Date:  2000-01       Impact factor: 4.272

3.  The basic helix-loop-helix transcription factors dHAND and eHAND exhibit dimerization characteristics that suggest complex regulation of function.

Authors:  B A Firulli; D B Hadzic; J R McDaid; A B Firulli
Journal:  J Biol Chem       Date:  2000-10-27       Impact factor: 5.157

4.  Transcripts encoding HAND genes are differentially expressed and regulated by BMP4 and GDNF in developing avian gut.

Authors:  Xiaodong Wu; Marthe J Howard
Journal:  Gene Expr       Date:  2002

5.  Enteric neuronal density contributes to the severity of intestinal inflammation.

Authors:  Kara Gross Margolis; Korey Stevanovic; Nima Karamooz; Zi Shan Li; Ankur Ahuja; Fabien D'Autréaux; Virginia Saurman; Alcmene Chalazonitis; Michael David Gershon
Journal:  Gastroenterology       Date:  2011-04-28       Impact factor: 22.682

Review 6.  Building a heart: implications for congenital heart disease.

Authors:  Deepak Srivastava
Journal:  J Nucl Cardiol       Date:  2003 Jan-Feb       Impact factor: 5.952

7.  Electrical stimulation of neonatal cardiomyocytes results in the sequential activation of nuclear genes governing mitochondrial proliferation and differentiation.

Authors:  Y Xia; L M Buja; R C Scarpulla; J B McMillin
Journal:  Proc Natl Acad Sci U S A       Date:  1997-10-14       Impact factor: 11.205

8.  Cardiomyogenic differentiation in cardiac myxoma expressing lineage-specific transcription factors.

Authors:  Hiroaki Kodama; Takashi Hirotani; Yusuke Suzuki; Satoshi Ogawa; Kazuto Yamazaki
Journal:  Am J Pathol       Date:  2002-08       Impact factor: 4.307

9.  Analysis of a Caenorhabditis elegans Twist homolog identifies conserved and divergent aspects of mesodermal patterning.

Authors:  B D Harfe; A Vaz Gomes; C Kenyon; J Liu; M Krause; A Fire
Journal:  Genes Dev       Date:  1998-08-15       Impact factor: 11.361

10.  The Polycomb-group gene Rae28 sustains Nkx2.5/Csx expression and is essential for cardiac morphogenesis.

Authors:  Manabu Shirai; Tomoaki Osugi; Hideyuki Koga; Yoshikazu Kaji; Eiki Takimoto; Issei Komuro; Junichi Hara; Takeshi Miwa; Keiko Yamauchi-Takihara; Yoshihiro Takihara
Journal:  J Clin Invest       Date:  2002-07       Impact factor: 14.808
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