[Pleomorphic storiform malignant fibrohistiocytoma of the larynx. Case report and anatomo-clinical considerations].

We have studied a rare case of malignant fibrous histiocytoma of the larynx, of the storiform-pleomorphic variety, diagnosed already as fibrosarcoma on two bioptical examinations performed to distance of a month the one from the other. The second biopsy showed an histological grade superior to the first and the patient came to death for lung metastasis two years later. The immunohistochemical study confirmed the mesenchimal origin of the tumor, excluding the presence of epithelial elements. Given the aggressive course, for the application of the different therapeutic protocols and for prognostic purposes it is underlined the need to make an attentive differential diagnosis also on histogenetic bases as regards the other mesenchimal and epithelial malignancies that they can simulate from near the histologic appearance. It proved very important, to such end, the immunohistochemical investigation, if correctly interpreted.