Literature DB >> 8532181

Pharmacological modulators of the inositol 1,4,5-trisphosphate receptor.

F Michelangeli1, M Mezna, S Tovey, L G Sayers.   

Abstract

Elevation of cytosolic calcium concentrations, induced by many neurotransmitters, plays a crucial role in neuronal function. Some neurotransmitters produce the second messenger InsP3 which activates an intracellular calcium channel (InsP3 receptor) usually located in the endoplasmic reticulum. This article undertakes a comprehensive survey of most pharmacological modulators of the InsP3 receptor so far reported. This review discusses in detail competitive antagonists, non-competitive antagonists and thiol reactive reagents, highlighting their modes of action and in some cases indicating drawbacks in their use.

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Year:  1995        PMID： 8532181     DOI： 10.1016/0028-3908(95)00053-9

Source DB:  PubMed          Journal:  Neuropharmacology        ISSN： 0028-3908            Impact factor:   5.250


  9 in total

1.  Effects of thimerosal on the transient kinetics of inositol 1,4,5-trisphosphate-induced Ca2+ release from cerebellar microsomes.

Authors:  M Mezna; F Michelangeli
Journal:  Biochem J       Date:  1997-07-01       Impact factor: 3.857

Review 2.  IP(3) receptors: toward understanding their activation.

Authors:  Colin W Taylor; Stephen C Tovey
Journal:  Cold Spring Harb Perspect Biol       Date:  2010-10-27       Impact factor: 10.005

3.  Inhibition of the cerebellar inositol 1,4,5-trisphosphate-sensitive Ca2+ channel by ethanol and other aliphatic alcohols.

Authors:  M Mezna; T Patchick; S Tovey; F Michelangeli
Journal:  Biochem J       Date:  1996-02-15       Impact factor: 3.857

4.  Growth of Pollen Tubes of Papaver rhoeas Is Regulated by a Slow-Moving Calcium Wave Propagated by Inositol 1,4,5-Trisphosphate.

Authors:  V. E. Franklin-Tong; B. K. Drobak; A. C. Allan; PAC. Watkins; A. J. Trewavas
Journal:  Plant Cell       Date:  1996-08       Impact factor: 11.277

Review 5.  Ca2+-stores in sperm: their identities and functions.

Authors:  Sarah Costello; Francesco Michelangeli; Katherine Nash; Linda Lefievre; Jennifer Morris; Gisela Machado-Oliveira; Christopher Barratt; Jackson Kirkman-Brown; Stephen Publicover
Journal:  Reproduction       Date:  2009-06-19       Impact factor: 3.906

6.  Calpain cleavage of the B isoform of Ins(1,4,5)P3 3-kinase separates the catalytic domain from the membrane anchoring domain.

Authors:  Krupa Pattni; Thomas H Millard; George Banting
Journal:  Biochem J       Date:  2003-11-01       Impact factor: 3.857

7.  Improving fertilization rate in ICSI cycles by adding myoinositol to the semen preparation procedures: a prospective, bicentric, randomized trial on sibling oocytes.

Authors:  Patrizia Rubino; Simone Palini; Sara Chigioni; Gianfranco Carlomagno; Antonella Quagliariello; Silvia De Stefani; Andrea Baglioni; Carlo Bulletti
Journal:  J Assist Reprod Genet       Date:  2015-01-20       Impact factor: 3.412

8.  Interactions of antagonists with subtypes of inositol 1,4,5-trisphosphate (IP3) receptor.

Authors:  Huma Saleem; Stephen C Tovey; Tedeusz F Molinski; Colin W Taylor
Journal:  Br J Pharmacol       Date:  2014-07       Impact factor: 8.739

9.  Augmented KCa2.3 Channel Feedback Regulation of Oxytocin Stimulated Uterine Strips from Nonpregnant Mice.

Authors:  Megan Zak; Bri Kestler; Trudy Cornwell; Mark S Taylor
Journal:  Int J Mol Sci       Date:  2021-12-18       Impact factor: 5.923
  9 in total

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