Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Human ADP-ribosylation factor-activated phosphatidylcholine-specific phospholipase D defines a new and highly conserved gene family.

Literature DB >> 8530346

Human ADP-ribosylation factor-activated phosphatidylcholine-specific phospholipase D defines a new and highly conserved gene family.

S M Hammond¹, Y M Altshuller, T C Sung, S A Rudge, K Rose, J Engebrecht, A J Morris, M A Frohman.

Abstract

Activation of phosphatidylcholine-specific phospholipase D (PLD) has been implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. We report here the identification of the first human PLD cDNA, which defines a new and highly conserved gene family. Characterization of recombinant human PLD1 reveals that it is membrane-associated, selective for phosphatidylcholine, stimulated by phosphatidylinositol 4,5-bisphosphate, activated by the monomeric G-protein ADP-ribosylation factor-1, and inhibited by oleate. PLD1 likely encodes the gene product responsible for the most widely studied endogenous PLD activity.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 1995 PMID： 8530346 DOI： 10.1074/jbc.270.50.29640

Source DB: PubMed Journal: J Biol Chem ISSN： 0021-9258 Impact factor: 5.157

Keyword Cloud
Cited

142 in total

1. Endocytosis and vesicular trafficking of immune complexes and activation of phospholipase D by the human high-affinity IgG receptor requires distinct phosphoinositide 3-kinase activities.

Authors: D J Gillooly; A J Melendez; A R Hockaday; M M Harnett; J M Allen
Journal: Biochem J Date: 1999-12-01 Impact factor: 3.857

2. Involvement of PL-D in the alternate signal tranduction pathway of macrophages induced by an external stimulus.

Authors: R Bandyopadhyay; M K Basu
Journal: Mol Cell Biochem Date: 2000-01 Impact factor: 3.396

3. Localization of phospholipase D1 to caveolin-enriched membrane via palmitoylation: implications for epidermal growth factor signaling.

Authors: Jung Min Han; Yong Kim; Jun Sung Lee; Chang Sup Lee; Byoung Dae Lee; Motoi Ohba; Toshio Kuroki; Pann-Ghill Suh; Sung Ho Ryu
Journal: Mol Biol Cell Date: 2002-11 Impact factor: 4.138

4. ADP-ribosylation-factor-regulated phospholipase D activity localizes to secretory vesicles and mobilizes to the plasma membrane following N-formylmethionyl-leucyl-phenylalanine stimulation of human neutrophils.

Authors: C P Morgan; H Sengelov; J Whatmore; N Borregaard; S Cockcroft
Journal: Biochem J Date: 1997-08-01 Impact factor: 3.857

5. Activation of exocytosis by cross-linking of the IgE receptor is dependent on ADP-ribosylation factor 1-regulated phospholipase D in RBL-2H3 mast cells: evidence that the mechanism of activation is via regulation of phosphatidylinositol 4,5-bisphosphate synthesis.

Authors: G Way; N O'luanaigh; S Cockcroft
Journal: Biochem J Date: 2000-02-15 Impact factor: 3.857

6. Elevated phospholipase D activity in H-Ras- but not K-Ras-transformed cells by the synergistic action of RalA and ARF6.

Authors: Lizhong Xu; Paul Frankel; Desmond Jackson; Thuy Rotunda; Rita L Boshans; Crislyn D'Souza-Schorey; David A Foster
Journal: Mol Cell Biol Date: 2003-01 Impact factor: 4.272

Human ADP-ribosylation factor-activated phosphatidylcholine-specific phospholipase D defines a new and highly conserved gene family.

1. Endocytosis and vesicular trafficking of immune complexes and activation of phospholipase D by the human high-affinity IgG receptor requires distinct phosphoinositide 3-kinase activities.

2. Involvement of PL-D in the alternate signal tranduction pathway of macrophages induced by an external stimulus.

3. Localization of phospholipase D1 to caveolin-enriched membrane via palmitoylation: implications for epidermal growth factor signaling.

4. ADP-ribosylation-factor-regulated phospholipase D activity localizes to secretory vesicles and mobilizes to the plasma membrane following N-formylmethionyl-leucyl-phenylalanine stimulation of human neutrophils.

5. Activation of exocytosis by cross-linking of the IgE receptor is dependent on ADP-ribosylation factor 1-regulated phospholipase D in RBL-2H3 mast cells: evidence that the mechanism of activation is via regulation of phosphatidylinositol 4,5-bisphosphate synthesis.

6. Elevated phospholipase D activity in H-Ras- but not K-Ras-transformed cells by the synergistic action of RalA and ARF6.

Review 7. Roles for the lipid-signaling enzyme MitoPLD in mitochondrial dynamics, piRNA biogenesis, and spermatogenesis.

Review 8. Phospholipase D/phosphatidic acid signal transduction: role and physiological significance in lung.

9. Phospholipase D1 and choline kinase-α are interactive targets in breast cancer.

10. Inhibition of phospholipase D alpha by N-acylethanolamines.