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Literature DB >> 8530027

Isolation, characterization, and precise physical localization of human CDX1, a caudal-type homeobox gene.

Abstract

The human CDX1 gene has been isolated from a small intestine cDNA library using a murine Cdx1 cDNA probe. The nucleotide sequence of CDX1 is 81% identical to murine Cdx1 and predicts a 265-amino-acid protein with 85% identity to the mouse protein (98% identity, including conservative amino acid changes). The CDX1 locus has been mapped to a cosmid contig from chromosome 5q31-q33, placing CDX1 approximately 100 kb distal to CSFIR. Expression of CDX1 in adults appears to be limited to the intestine and colon by Northern analysis, suggesting a possible role in the terminal differentiation of the intestine. Further analysis of CDX1 should elucidate the function of caudal-type homeobox genes in human development.

Entities: Gene Species

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Year: 1995 PMID： 8530027 DOI： 10.1006/geno.1995.1132

Source DB: PubMed Journal: Genomics ISSN： 0888-7543 Impact factor: 5.736

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Cited

14 in total

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Review 4. Interaction of sonic hedgehog (SHH) pathway with cancer stem cell genes in gastric cancer.

Authors: Ali Akbar Samadani; Haleh Akhavan-Niaki
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5. Expression of an intestine-specific transcription factor (CDX1) in intestinal metaplasia and in subsequently developed intestinal type of cholangiocarcinoma in rat liver.

Authors: P Ren; D G Silberg; A E Sirica
Journal: Am J Pathol Date: 2000-02 Impact factor: 4.307

Isolation, characterization, and precise physical localization of human CDX1, a caudal-type homeobox gene.

Review 1. Cdx genes, inflammation, and the pathogenesis of intestinal metaplasia.

2. Altered expression of TFF-1 and CES-2 in Barrett's Esophagus and associated adenocarcinomas.

3. Prognostic factors for ampullary adenocarcinomas: tumor stage, tumor histology, tumor location, immunohistochemistry and microsatellite instability.

Review 4. Interaction of sonic hedgehog (SHH) pathway with cancer stem cell genes in gastric cancer.

5. Expression of an intestine-specific transcription factor (CDX1) in intestinal metaplasia and in subsequently developed intestinal type of cholangiocarcinoma in rat liver.

Review 6. Regulation of self-renewal and differentiation by the intestinal stem cell niche.

7. Gastrointestinal differentiation marker Cytokeratin 20 is regulated by homeobox gene CDX1.

8. Temporal and spatial expression of caudal-type homeobox proteins in the midgut of human embryos.

Review 9. Molecular basis of Barrett's oesophagus and oesophageal adenocarcinoma.

10. Mutations and down-regulation of CDX1 in children with anorectal malformations.