Literature DB >> 8529893

Clavulanic acid biosynthesis in Streptomyces clavuligerus: gene cloning and characterization.

J E Hodgson1, A P Fosberry, N S Rawlinson, H N Ross, R J Neal, J C Arnell, A J Earl, E J Lawlor.   

Abstract

Seven classes of Streptomyces clavuligerus mutants defective in clavulanic acid (CLA) biosynthesis have been identified and used to clone the chromosomal DNA encoding eight CLA biosynthetic genes. The complete sequences of three and the partial sequences of two of these biosynthetic genes are reported, together with their known or predicted functions.

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Year:  1995        PMID： 8529893     DOI： 10.1016/0378-1119(95)00560-9

Source DB:  PubMed          Journal:  Gene        ISSN： 0378-1119            Impact factor:   3.688


  15 in total

1.  Enzymes catalyzing the early steps of clavulanic acid biosynthesis are encoded by two sets of paralogous genes in Streptomyces clavuligerus.

Authors:  S E Jensen; K J Elder; K A Aidoo; A S Paradkar
Journal:  Antimicrob Agents Chemother       Date:  2000-03       Impact factor: 5.191

2.  Five additional genes are involved in clavulanic acid biosynthesis in Streptomyces clavuligerus.

Authors:  S E Jensen; A S Paradkar; R H Mosher; C Anders; P H Beatty; M J Brumlik; A Griffin; B Barton
Journal:  Antimicrob Agents Chemother       Date:  2004-01       Impact factor: 5.191

3.  X-ray crystal structure of ornithine acetyltransferase from the clavulanic acid biosynthesis gene cluster.

Authors:  Jonathan M Elkins; Nadia J Kershaw; Christopher J Schofield
Journal:  Biochem J       Date:  2005-01-15       Impact factor: 3.857

4.  Deletion of the pyc gene blocks clavulanic acid biosynthesis except in glycerol-containing medium: evidence for two different genes in formation of the C3 unit.

Authors:  R Pérez-Redondo; A Rodríguez-García; J F Martín; P Liras
Journal:  J Bacteriol       Date:  1999-11       Impact factor: 3.490

5.  The paralogous pairs of genes involved in clavulanic acid and clavam metabolite biosynthesis are differently regulated in Streptomyces clavuligerus.

Authors:  Kapil Tahlan; Cecilia Anders; Susan E Jensen
Journal:  J Bacteriol       Date:  2004-09       Impact factor: 3.490

6.  Investigation of the Streptomyces clavuligerus cephamycin C gene cluster and its regulation by the CcaR protein.

Authors:  D C Alexander; S E Jensen
Journal:  J Bacteriol       Date:  1998-08       Impact factor: 3.490

7.  Two proteins with ornithine acetyltransferase activity show different functions in Streptomyces clavuligerus: Oat2 modulates clavulanic acid biosynthesis in response to arginine.

Authors:  A de la Fuente; J F Martín; A Rodríguez-García; P Liras
Journal:  J Bacteriol       Date:  2004-10       Impact factor: 3.490

8.  Alanylclavam biosynthetic genes are clustered together with one group of clavulanic acid biosynthetic genes in Streptomyces clavuligerus.

Authors:  Nathan J Zelyas; Hui Cai; Thomas Kwong; Susan E Jensen
Journal:  J Bacteriol       Date:  2008-10-17       Impact factor: 3.490

9.  Streptomyces clavuligerus has a second copy of the proclavaminate amidinohydrolase gene.

Authors:  Susan E Jensen; Annie Wong; Alison Griffin; Barry Barton
Journal:  Antimicrob Agents Chemother       Date:  2004-02       Impact factor: 5.191

10.  Two oligopeptide-permease-encoding genes in the clavulanic acid cluster of Streptomyces clavuligerus are essential for production of the beta-lactamase inhibitor.

Authors:  Luis M Lorenzana; Rosario Pérez-Redondo; Irene Santamarta; Juan F Martín; Paloma Liras
Journal:  J Bacteriol       Date:  2004-06       Impact factor: 3.490
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