| Literature DB >> 8529875 |
H Decker1, J Rohr, H Motamedi, H Zähner, C R Hutchinson.
Abstract
The genes for the production of elloramycin (ELM) from Streptomyces olivaceus (So) Tü2353 were cloned using a polyketide synthase gene probe from the tetracenomycin pathway. A cosmid clone (16F4) isolated from a gene library of So Tü2353 conferred tetracenomycin C and ELM resistance to S. lividans TK64 and complemented a mutation in So Tü2353R. Introduction of cosmid 16F4 into S. lividans TK64 resulted in the production of 8-demethyl-tetracenomycin C, an intermediate of ELM biosynthesis.Entities:
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Year: 1995 PMID： 8529875 DOI： 10.1016/0378-1119(95)00573-7
Source DB: PubMed Journal: Gene ISSN： 0378-1119 Impact factor: 3.688