| Literature DB >> 8528247 |
J Galli1, L S Li, A Glaser, C G Ostenson, H Jiao, H Fakhrai-Rad, H J Jacob, E S Lander, H Luthman.
Abstract
Non-insulin dependent diabetes mellitus (NIDDM) is a major public health problem, but its aetiology remains poorly understood. We have performed a comprehensive study of the genetic basis of diabetes in the Goto-Kakizaki (GK) rat, the most widely used animal model of non-obese NIDDM. The genetic dissection of NIDDM using this model has allowed us to map three independent loci involved in the disease. In addition, we identify a major factor affecting body weight, but not glucose tolerance, on chromosome 7 and map a further 10 regions that are suggestive for linkage. We conclude that NIDDM is polygenic and fasting hyperglycaemia and postprandial hyperglycaemia clearly have distinct genetic bases.Entities:
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Year: 1996 PMID： 8528247 DOI： 10.1038/ng0196-31
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330