Literature DB >> 8527838

The Rac and Rho pathways as a source of drug targets for Ras-mediated malignancies.

M Symons1.   

Abstract

The small GTP-binding proteins Rac and Rho are key control elements in the reorganization of the actin cytoskeleton induced by growth factors or oncogenic Ras. It has been established recently that Rac and Rho also play a crucial role in Ras transformation. This suggests that the elements in the pathways regulated by Rac and Rho are valid targets for cancer therapy. Several important components of those signaling pathways have now have identified.

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Year:  1995        PMID： 8527838     DOI： 10.1016/0958-1669(95)80110-3

Source DB:  PubMed          Journal:  Curr Opin Biotechnol        ISSN： 0958-1669            Impact factor:   9.740


  14 in total

Review 1.  Targeting signal transduction for disease therapy.

Authors:  A Levitzki
Journal:  Med Oncol       Date:  1997-06       Impact factor: 3.064

2.  Cdc42 regulates anchorage-independent growth and is necessary for Ras transformation.

Authors:  R G Qiu; A Abo; F McCormick; M Symons
Journal:  Mol Cell Biol       Date:  1997-06       Impact factor: 4.272

3.  A role for Pak protein kinases in Schwann cell transformation.

Authors:  Y Tang; S Marwaha; J L Rutkowski; G I Tennekoon; P C Phillips; J Field
Journal:  Proc Natl Acad Sci U S A       Date:  1998-04-28       Impact factor: 11.205

4.  Identification of a novel Rac1-interacting protein involved in membrane ruffling.

Authors:  L Van Aelst; T Joneson; D Bar-Sagi
Journal:  EMBO J       Date:  1996-08-01       Impact factor: 11.598

5.  Cell-cycle regulated expression and serine phosphorylation of the myristylated protein kinase C substrate, SSeCKS: correlation with culture confluency, cell cycle phase and serum response.

Authors:  P J Nelson; I H Gelman
Journal:  Mol Cell Biochem       Date:  1997-10       Impact factor: 3.396

6.  Functional analysis of the interaction between the small GTP binding protein Cdc42 and the Ste20 protein kinase in yeast.

Authors:  M Peter; A M Neiman; H O Park; M van Lohuizen; I Herskowitz
Journal:  EMBO J       Date:  1996-12-16       Impact factor: 11.598

7.  A rac homolog is required for induction of hyphal growth in the dimorphic yeast Yarrowia lipolytica.

Authors:  C A Hurtado; J M Beckerich; C Gaillardin; R A Rachubinski
Journal:  J Bacteriol       Date:  2000-05       Impact factor: 3.490

8.  The MLK-related kinase (MRK) is a novel RhoC effector that mediates lysophosphatidic acid (LPA)-stimulated tumor cell invasion.

Authors:  Olga Korkina; Zhiwan Dong; Allison Marullo; Gregg Warshaw; Marc Symons; Rosamaria Ruggieri
Journal:  J Biol Chem       Date:  2013-01-14       Impact factor: 5.157

9.  Novel Cdc42-binding proteins Gic1 and Gic2 control cell polarity in yeast.

Authors:  J L Brown; M Jaquenoud; M P Gulli; J Chant; M Peter
Journal:  Genes Dev       Date:  1997-11-15       Impact factor: 11.361

10.  Distinct effects of Rac1 on differentiation of primary avian myoblasts.

Authors:  R Gallo; M Serafini; L Castellani; G Falcone; S Alemà
Journal:  Mol Biol Cell       Date:  1999-10       Impact factor: 4.138
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