Literature DB >> 8527741

Two types of calcium channels sensitive to omega-agatoxin- TK in cultured rat hippocampal neurones.

T Teramoto1, T Niidome, T Miyagawa, Y Nishizawa, K Katayama, K Sawada.   

Abstract

We characterized the electrophysiological properties of calcium channels in cultured rat hippocampal neurones using omega-agatoxin-TK (omega-Aga-TK) and compared them with those of the P-type channel and the BI (alpha 1A) channel which resembles the Q-type channel. Two types of omega-Aga-TK-sensitive calcium channels were detected in hippocampal neurones. The first type showed slow inactivation, high sensitivity to omega-Aga-TK and low reversibility from omega-Aga-TK-induced block, resembling the P-type channel. The second type showed fast inactivation, low sensitivity to omega-Aga-TK and high reversibility from omega-Aga-TK-induced block. These results suggest that the second type of calcium channel (Q-type-like) plays a prominent role in the hippocampal synaptic transmission.

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Year:  1995        PMID： 8527741     DOI： 10.1097/00001756-199508000-00022

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  11 in total

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