Literature DB >> 8527727

Regional difference of high voltage-activated Ca2+ channels in rat CNS neurones.

H Ishibashi1, J S Rhee, N Akaike.   

Abstract

The diversity of high voltage-activated (HVA) Ca2+ channels in rat CNS neurones was investigated with the nystatin perforated patch recording configuration. The neurones were freshly dissociated from rat substantia nigra, ventromedial hypothalamus, tuberomammillary nucleus, nucleus tractus solitarius, hippocampal CA1 region and cerebellum. Five different types of HVA Ca2+ channels were distinguished pharmacologically; dihydropyridine sensitive L-type, omega-conotoxin-GVIA sensitive N-type, omega-agatoxin-IVA sensitive P-type, omega-conotoxin-MVIIC sensitive Q-type, and R-type which is insensitive to these organic Ca2+ antagonists. The results showed clearly that the five subtypes of HVA Ca2+ channels differ considerably in their distribution among various CNS regions.

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Year:  1995        PMID: 8527727     DOI: 10.1097/00001756-199508000-00008

Source DB:  PubMed          Journal:  Neuroreport        ISSN: 0959-4965            Impact factor:   1.837


  9 in total

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7.  Modulation of voltage-gated calcium channels by orphanin FQ in freshly dissociated hippocampal neurons.

Authors:  F Knoflach; R K Reinscheid; O Civelli; J A Kemp
Journal:  J Neurosci       Date:  1996-11-01       Impact factor: 6.167

8.  A selective T-type Ca2+ channel blocker R(-) efonidipine.

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Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2008-02-16       Impact factor: 3.000

9.  The Ca(V)2.3 Ca(2+) channel subunit contributes to R-type Ca(2+) currents in murine hippocampal and neocortical neurones.

Authors:  Dmitry Sochivko; Alexey Pereverzev; Neil Smyth; Cornelia Gissel; Toni Schneider; Heinz Beck
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  9 in total

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