Literature DB >> 8527489

New aspects of the physiological significance of NAD, poly ADP-ribose and cyclic ADP-ribose.

H Okamoto1, S Takasawa, A Tohgo.   

Abstract

Cyclic ADP-ribose is generated from NAD+ in glucose-stimulated beta-cells by CD38. Cyclic ADP-ribose mobilizes Ca2+ from the endoplasmic reticulum to secrete insulin. The amino acid residues of Cys-119 and Cys-201 in CD38 are essential for the synthesis and hydrolysis of cyclic ADP-ribose.

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Year:  1995        PMID： 8527489     DOI： 10.1016/0300-9084(96)88146-6

Source DB:  PubMed          Journal:  Biochimie        ISSN： 0300-9084            Impact factor:   4.079


  5 in total

1.  The CD38-cyclic ADP-ribose signaling system in insulin secretion.

Authors:  H Okamoto
Journal:  Mol Cell Biochem       Date:  1999-03       Impact factor: 3.396

2.  TRPM2 functions as a lysosomal Ca2+-release channel in beta cells.

Authors:  Ingo Lange; Shinichiro Yamamoto; Santiago Partida-Sanchez; Yasuo Mori; Andrea Fleig; Reinhold Penner
Journal:  Sci Signal       Date:  2009-05-19       Impact factor: 8.192

3.  Autoantibodies against CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase) that impair glucose-induced insulin secretion in noninsulin- dependent diabetes patients.

Authors:  F Ikehata; J Satoh; K Nata; A Tohgo; T Nakazawa; I Kato; S Kobayashi; T Akiyama; S Takasawa; T Toyota; H Okamoto
Journal:  J Clin Invest       Date:  1998-07-15       Impact factor: 14.808

4.  Okamoto model for necrosis and its expansions, CD38-cyclic ADP-ribose signal system for intracellular Ca2+ mobilization and Reg (Regenerating gene protein)-Reg receptor system for cell regeneration.

Authors:  Hiroshi Okamoto; Shin Takasawa
Journal:  Proc Jpn Acad Ser B Phys Biol Sci       Date:  2021       Impact factor: 3.493

Review 5.  CD38-Cyclic ADP-Ribose Signal System in Physiology, Biochemistry, and Pathophysiology.

Authors:  Shin Takasawa
Journal:  Int J Mol Sci       Date:  2022-04-13       Impact factor: 6.208
  5 in total

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