Literature DB >> 8527288

Differential actions of desipramine on sympathoadrenal release of noradrenaline and adrenaline.

G Eisenhofer1, P Friberg, D S Goldstein, M Esler.   

Abstract

Spillovers noradrenaline (NA) and adrenaline (A) into plasma were examined before and after i.v. administration of 0.3-0.5 mg kg-1 desipramine (DMI) in 19 normal volunteers. DMI decreased the total body spillover of NA by 20 +/- 4%, but increased that of A by 45 +/- 10%. The results indicate differential sympathoadrenal actions of DMI, characterized by inhibition of NA release from sympathetic nerves and stimulation of A secretion from the adrenals. These effects of DMI provide an explanation for some of the cardiovascular complications of tricyclic antidepressant therapy and may also help to explain how sympathoadrenal function is differentially regulated.

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Year:  1995        PMID： 8527288      PMCID： PMC1365106          DOI： 10.1111/j.1365-2125.1995.tb05782.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  14 in total

1.  Differential effects of central and peripheral desipramine on sympathoadrenal function and heart rate in conscious rabbits.

Authors:  P K Dorward; T Saigusa; G Eisenhofer
Journal:  J Cardiovasc Pharmacol       Date:  1991-04       Impact factor: 3.105

2.  Effects of desipramine on sympathetic nerve firing and norepinephrine spillover to plasma in humans.

Authors:  M D Esler; G Wallin; P K Dorward; G Eisenhofer; R Westerman; I Meredith; G Lambert; H S Cox; G Jennings
Journal:  Am J Physiol       Date:  1991-04

3.  Cocaine acts in the central nervous system to inhibit sympathetic neural activity.

Authors:  V F Raczkowski; Y M Hernandez; H K Erzouki; T P Abrahams; A K Mandal; P Hamosh; E Friedman; J A Quest; K L Dretchen; R A Gillis
Journal:  J Pharmacol Exp Ther       Date:  1991-04       Impact factor: 4.030

4.  Differential control of adrenal and renal sympathetic nerve activity during hemorrhagic hypotension in rats.

Authors:  R G Victor; P Thorén; D A Morgan; A L Mark
Journal:  Circ Res       Date:  1989-04       Impact factor: 17.367

5.  Differences in the neuronal removal of circulating epinephrine and norepinephrine.

Authors:  G Eisenhofer; M D Esler; H S Cox; I T Meredith; G L Jennings; J E Brush; D S Goldstein
Journal:  J Clin Endocrinol Metab       Date:  1990-06       Impact factor: 5.958

6.  Simultaneous determination of plasma noradrenaline and adrenaline kinetics. Responses to nitroprusside-induced hypotension and 2-deoxyglucose-induced glucopenia in the rabbit.

Authors:  O S Medvedev; M D Esler; J A Angus; H S Cox; G Eisenhofer
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1990-03       Impact factor: 3.000

7.  Sympathetic nervous system activity in major depression. Basal and desipramine-induced alterations in plasma norepinephrine kinetics.

Authors:  R C Veith; N Lewis; O A Linares; R F Barnes; M A Raskind; E C Villacres; M M Murburg; E A Ashleigh; S Castillo; E R Peskind
Journal:  Arch Gen Psychiatry       Date:  1994-05

8.  Effects of aging on epinephrine secretion and regional release of epinephrine from the human heart.

Authors:  M Esler; D Kaye; J Thompson; G Jennings; H Cox; A Turner; G Lambert; D Seals
Journal:  J Clin Endocrinol Metab       Date:  1995-02       Impact factor: 5.958

9.  Effects of desipramine hydrochloride on peripheral sympathetic nerve activity.

Authors:  M D Cohen; J Finberg; M Dibner-Dunlap; S N Yuih; M D Thames
Journal:  Am J Physiol       Date:  1990-04

10.  Centrally mediated release by cocaine of endogenous epinephrine and norepinephrine from the sympathoadrenal medullary system of unanesthetized rats.

Authors:  C C Chiueh; I J Kopin
Journal:  J Pharmacol Exp Ther       Date:  1978-04       Impact factor: 4.030
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Authors:  Koji Shinkai; Yumiko Toyohira; Reiji Yoshimura; Masato Tsutsui; Susume Ueno; Jun Nakamura; Nobuyuki Yanagihara
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2007-01-09       Impact factor: 3.000

4.  Sympathetic nerve traffic and circulating norepinephrine levels in RGS2-deficient mice.

Authors:  Jens Tank; Michael Obst; Andrè Diedrich; Robert J Brychta; Kendall J Blumer; Karsten Heusser; Jens Jordan; Friedrich C Luft; Volkmar Gross
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  4 in total

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