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Literature DB >> 8527274

Comparative effects of antifungal agents on zidovudine glucuronidation by human liver microsomes.

E Sampol¹, B Lacarelle, J F Rajaonarison, J Catalin, A Durand.

Abstract

Zidovudine (ZDV) is extensively metabolised by the liver to an inactive glucuronide (GZDV). Since ZDV is often administered with antimycotic drugs, we studied the effect of six systemic antifungal agents on the in vitro glucuronidation of ZDV by human liver microsomes. 5-fluorocytosine and itraconazole had no inhibitory effect whereas amphotericine B, ketoconazole, miconazole and fluconazole inhibited in vitro GZDV formation (Ki values were 0.13, 0.08, 0.18 and 1.4 mM respectively).

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Year: 1995 PMID： 8527274 PMCID： PMC1365033 DOI： 10.1111/j.1365-2125.1995.tb04540.x

Source DB: PubMed Journal: Br J Clin Pharmacol ISSN： 0306-5251 Impact factor: 4.335

17 in total

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