Literature DB >> 8527008

The use of famotidine in the treatment of Parkinson's disease: a pilot study.

S P Molinari1, R Kaminski, A Di Rocco, M D Yahr.   

Abstract

Seven patients with idiopathic Parkinson's disease were enrolled in a ten week study to evaluate the efficacy of famotidine, an histamine H2-antagonist, in the treatment of bradyphrenia. Patients received famotidine 80 mg/day for a period of six weeks and were evaluated with neuropsychological tests. Overall, patients demonstrated improvement in variables measured. Some patients also reported an improvement in their motor symptoms.

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Year:  1995        PMID: 8527008     DOI: 10.1007/bf02259665

Source DB:  PubMed          Journal:  J Neural Transm Park Dis Dement Sect        ISSN: 0936-3076


  6 in total

1.  Inverse agonism of histamine H2 antagonist accounts for upregulation of spontaneously active histamine H2 receptors.

Authors:  M J Smit; R Leurs; A E Alewijnse; J Blauw; G P Van Nieuw Amerongen; Y Van De Vrede; E Roovers; H Timmerman
Journal:  Proc Natl Acad Sci U S A       Date:  1996-06-25       Impact factor: 11.205

Review 2.  An overview of famotidine polymorphs: solid-state characteristics, thermodynamics, polymorphic transformation and quality control.

Authors:  Shan-Yang Lin
Journal:  Pharm Res       Date:  2014-03-01       Impact factor: 4.200

3.  Inflammatory Animal Model for Parkinson's Disease: The Intranigral Injection of LPS Induced the Inflammatory Process along with the Selective Degeneration of Nigrostriatal Dopaminergic Neurons.

Authors:  A Machado; A J Herrera; J L Venero; M Santiago; R M de Pablos; R F Villarán; A M Espinosa-Oliva; S Argüelles; M Sarmiento; M J Delgado-Cortés; R Mauriño; J Cano
Journal:  ISRN Neurol       Date:  2011-04-17

4.  Genetic variability of histamine receptors in patients with Parkinson's disease.

Authors:  Elena García-Martín; P Ayuso; Antonio Luengo; Carmen Martínez; José Ag Agúndez
Journal:  BMC Med Genet       Date:  2008-03-17       Impact factor: 2.103

Review 5.  Thr105Ile (rs11558538) polymorphism in the histamine N-methyltransferase (HNMT) gene and risk for Parkinson disease: A PRISMA-compliant systematic review and meta-analysis.

Authors:  Félix Javier Jiménez-Jiménez; Hortensia Alonso-Navarro; Elena García-Martín; José A G Agúndez
Journal:  Medicine (Baltimore)       Date:  2016-07       Impact factor: 1.889

Review 6.  The Histaminergic System in Neuropsychiatric Disorders.

Authors:  Li Cheng; Jiaying Liu; Zhong Chen
Journal:  Biomolecules       Date:  2021-09-11
  6 in total

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