OBJECTIVE: The aim of this study was to compare levels of CSF somatostatin (somatotropin release-inhibiting factor) in drug-free patients with different major psychiatric disorders. METHOD: CSF somatostatin concentrations were measured in 66 drug-free inpatients with Research Diagnostic Criteria diagnoses of schizophrenia, major depressive disorder, manic disorder, or schizoaffective disorder. RESULTS: In comparison with both the patients with schizophrenia and the patients with schizoaffective disorder, the manic patients had markedly elevated CSF somatostatin concentrations. The depressed patients had significantly higher levels than the schizophrenic patients. CONCLUSIONS: Mania is associated with relatively higher CSF somatostatin concentrations.
OBJECTIVE: The aim of this study was to compare levels of CSF somatostatin (somatotropin release-inhibiting factor) in drug-free patients with different major psychiatric disorders. METHOD: CSF somatostatin concentrations were measured in 66 drug-free inpatients with Research Diagnostic Criteria diagnoses of schizophrenia, major depressive disorder, manic disorder, or schizoaffective disorder. RESULTS: In comparison with both the patients with schizophrenia and the patients with schizoaffective disorder, the manicpatients had markedly elevated CSF somatostatin concentrations. The depressedpatients had significantly higher levels than the schizophrenicpatients. CONCLUSIONS:Mania is associated with relatively higher CSF somatostatin concentrations.
Authors: J D Bremner; J Licinio; A Darnell; J H Krystal; M J Owens; S M Southwick; C B Nemeroff; D S Charney Journal: Am J Psychiatry Date: 1997-05 Impact factor: 18.112
Authors: S J Evans; P V Choudary; M P Vawter; J Li; J H Meador-Woodruff; J F Lopez; S M Burke; R C Thompson; R M Myers; E G Jones; W E Bunney; S J Watson; H Akil Journal: Neurobiol Dis Date: 2003-11 Impact factor: 5.996