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Literature DB >> 8525800

Endothelial lipopigment as an indicator of alpha-tocopherol deficiency in two equine neurodegenerative diseases.

J F Cummings¹, A de Lahunta, H O Mohammed, T J Divers, B A Summers, B A Valentine, C A Jackson.

Abstract

Two spontaneous neurodegenerative diseases of the horse, equine motor neuron disease (EMND) and equine degenerative myeloencephalopathy (EDM), have been associated with alpha-tocopherol deficiency, and both were characterized by prominent accumulations of endothelial lipopigment in the small vessels of the spinal cord. These endothelial pigment deposits appear to be reversible. In EMND horses pasture-supplemented for 9 months or more after the progression of weakness and wasting had arrested, there was very little endothelial lipopigment. The origin and the potential effects of these endothelial lipopigment accumulations are discussed.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1995 PMID： 8525800 DOI： 10.1007/bf00296510

Source DB: PubMed Journal: Acta Neuropathol ISSN： 0001-6322 Impact factor: 17.088

29 in total

1. Equine motor neuron disease; a preliminary report.

Authors: J F Cummings; A de Lahunta; C George; L Fuhrer; B A Valentine; B J Cooper; B A Summers; C R Huxtable; H O Mohammed
Journal: Cornell Vet Date: 1990-10

2. Spinal ataxia in zebras. Comparison with the wobbler syndrome of horses.

Authors: R J Montali; M Bush; R M Sauer; C W Gray; W A Xanten
Journal: Vet Pathol Date: 1974 Impact factor: 2.221

3. Acquired equine motor neuron disease.

Authors: B A Valentine; A de Lahunta; C George; B A Summers; J F Cummings; T J Divers; H O Mohammed
Journal: Vet Pathol Date: 1994-01 Impact factor: 2.221

4. Spinal cord disease in the horse.

Authors: I G Mayhew; A deLahunta; R H Whitlock; L Krook; J B Tasker
Journal: Cornell Vet Date: 1978-01

5. Risk factors associated with equine motor neuron disease: a possible model for human MND.

Authors: H O Mohammed; J F Cummings; T J Divers; B Valentine; A de Lahunta; B Summers; B R Farrow; K Trembicki-Graves; A Mauskopf
Journal: Neurology Date: 1993-05 Impact factor: 9.910

6. Myopathy in vitamin E deficient rats: muscle fibre necrosis associated with disturbances of mitochondrial function.

Authors: P K Thomas; J M Cooper; R H King; J M Workman; A H Schapira; M A Goss-Sampson; D P Muller
Journal: J Anat Date: 1993-12 Impact factor: 2.610

7. Serially determined plasma alpha-tocopherol concentrations and results of the oral vitamin E absorption test in clinically normal horses and in horses with degenerative myeloencephalopathy.

Authors: L L Blythe; A M Craig; E D Lassen; K E Rowe; L H Appell
Journal: Am J Vet Res Date: 1991-06 Impact factor: 1.156

Endothelial lipopigment as an indicator of alpha-tocopherol deficiency in two equine neurodegenerative diseases.

1. Equine motor neuron disease; a preliminary report.

2. Spinal ataxia in zebras. Comparison with the wobbler syndrome of horses.

3. Acquired equine motor neuron disease.

4. Spinal cord disease in the horse.

5. Risk factors associated with equine motor neuron disease: a possible model for human MND.

6. Myopathy in vitamin E deficient rats: muscle fibre necrosis associated with disturbances of mitochondrial function.

7. Serially determined plasma alpha-tocopherol concentrations and results of the oral vitamin E absorption test in clinically normal horses and in horses with degenerative myeloencephalopathy.

8. Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase.

Review 9. Equine degenerative myeloencephalopathy.

10. Modulation of hydrogen peroxide release from vascular endothelial cells by oxygen.

1. Vitamin E deficiency and risk of equine motor neuron disease.