| Literature DB >> 8525692 |
O Ofori-Anyinam1, R Vrijsen, P Kronenberger, A Boeyé.
Abstract
Polioviruses type 1 (Mahoney) and type 3 (Sabin) were treated with the antiviral pyridazinamine R78206 by first binding the compound to the virus and then removing unbound compound by dialysis. As a result of this treatment, both poliovirus strains were protected against thermal inactivation at 46 degrees C. The R78206 treatment did not cause inactivation except with the Sabin 3 strain at high R78206 concentrations.Entities:
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Year: 1995 PMID： 8525692 DOI： 10.1016/0264-410x(95)00036-z
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641