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Literature DB >> 8524390

Nucleation of microtubule assembly by a gamma-tubulin-containing ring complex.

Y Zheng¹, M L Wong, B Alberts, T Mitchison.

Abstract

The highly conserved protein gamma-tubulin is required for microtubule nucleation in vivo. When viewed in the electron microscope, a highly purified gamma-tubulin complex from Xenopus consisting of at least seven different proteins is seen to have an open ring structure. This complex acts as an active microtubule-nucleating unit which can cap the minus ends of microtubules in vitro.

Entities: Gene Species

Mesh：

Substances：
Tubulin

Year: 1995 PMID： 8524390 DOI： 10.1038/378578a0

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

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Cited

305 in total

1. The TACC domain identifies a family of centrosomal proteins that can interact with microtubules.

Authors: F Gergely; C Karlsson; I Still; J Cowell; J Kilmartin; J W Raff
Journal: Proc Natl Acad Sci U S A Date: 2000-12-19 Impact factor: 11.205

2. Components of an SCF ubiquitin ligase localize to the centrosome and regulate the centrosome duplication cycle.

Authors: E Freed; K R Lacey; P Huie; S A Lyapina; R J Deshaies; T Stearns; P K Jackson
Journal: Genes Dev Date: 1999-09-01 Impact factor: 11.361

3. The Drosophila wispy gene is required for RNA localization and other microtubule-based events of meiosis and early embryogenesis.

Authors: A E Brent; A MacQueen; T Hazelrigg
Journal: Genetics Date: 2000-04 Impact factor: 4.562

4. Nuclear gamma-tubulin during acentriolar plant mitosis.

Authors: P Binarová; V Cenklová; B Hause; E Kubátová; M Lysák; J Dolezel; L Bögre; P Dráber
Journal: Plant Cell Date: 2000-03 Impact factor: 11.277

5. Cytoplasmic dynein-mediated assembly of pericentrin and gamma tubulin onto centrosomes.

Authors: A Young; J B Dictenberg; A Purohit; R Tuft; S J Doxsey
Journal: Mol Biol Cell Date: 2000-06 Impact factor: 4.138

6. Identification of ribonucleotide reductase protein R1 as an activator of microtubule nucleation in Xenopus egg mitotic extracts.

Authors: S Takada; T Shibata; Y Hiraoka; H Masuda
Journal: Mol Biol Cell Date: 2000-12 Impact factor: 4.138

Nucleation of microtubule assembly by a gamma-tubulin-containing ring complex.

1. The TACC domain identifies a family of centrosomal proteins that can interact with microtubules.

2. Components of an SCF ubiquitin ligase localize to the centrosome and regulate the centrosome duplication cycle.

3. The Drosophila wispy gene is required for RNA localization and other microtubule-based events of meiosis and early embryogenesis.

4. Nuclear gamma-tubulin during acentriolar plant mitosis.

5. Cytoplasmic dynein-mediated assembly of pericentrin and gamma tubulin onto centrosomes.

6. Identification of ribonucleotide reductase protein R1 as an activator of microtubule nucleation in Xenopus egg mitotic extracts.

7. The Golgi complex is a microtubule-organizing organelle.

8. Self-organization of a radial microtubule array by dynein-dependent nucleation of microtubules.

9. Reconstitution and characterization of budding yeast gamma-tubulin complex.

10. Association of brain gamma-tubulins with alpha beta-tubulin dimers.