| Literature DB >> 8523528 |
Abstract
Human foamy virus (HFV) is a retrovirus of the spumavirus family. We have constructed vectors based on HFV that encode neomycin phosphotransferase and alkaline phosphatase. These vectors are able to transduce a wide variety of vertebrate cells by integration of the vector genome. Unlike vectors based on murine leukemia virus, HFV vectors are not inactivated by human serum, and they transduce stationary-phase cultures more efficiently than murine leukemia virus vectors. These properties, as well as their large packaging capacity, make HFV vectors promising gene transfer vehicles.Entities:
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Year: 1996 PMID: 8523528 PMCID: PMC189807
Source DB: PubMed Journal: J Virol ISSN: 0022-538X Impact factor: 5.103