Literature DB >> 8522051

Genetic analysis of NIDDM. The study of quantitative traits.

S Ghosh1, N J Schork.   

Abstract

Many studies are in progress worldwide to elucidate the genetics of NIDDM. Nevertheless, few articles are available that combine the interdisciplinary fields of medicine, genetics, physiology, and statistics in order to provide the scientific rationale for such an endeavor. Here we describe the methodology and background necessary to study the genetics of NIDDM and discuss how to analyze the data. We also provide a detailed bibliography for researchers and a glossary for those who are not experts in the field. In particular, we wish to emphasize the analysis of intermediate quantitative traits as a means to dissect the genetic basis of NIDDM.

Entities:  

Mesh：

Year:  1996        PMID： 8522051     DOI： 10.2337/diab.45.1.1

Source DB:  PubMed          Journal:  Diabetes        ISSN： 0012-1797            Impact factor:   9.461


  19 in total

1.  Joint multipoint linkage analysis of multivariate qualitative and quantitative traits. I. Likelihood formulation and simulation results.

Authors:  J T Williams; P Van Eerdewegh; L Almasy; J Blangero
Journal:  Am J Hum Genet       Date:  1999-10       Impact factor: 11.025

Review 2.  Quantitative trait linkage studies of diabetes-related traits.

Authors:  Robert L Hanson; William C Knowler
Journal:  Curr Diab Rep       Date:  2003-04       Impact factor: 4.810

Review 3.  Genomics of type 2 diabetes mellitus: implications for the clinician.

Authors:  Elliot S Stolerman; Jose C Florez
Journal:  Nat Rev Endocrinol       Date:  2009-06-30       Impact factor: 43.330

Review 4.  Diabetes.

Authors:  T Mandrup-Poulsen
Journal:  BMJ       Date:  1998-04-18

5.  Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2.

Authors:  Y Kido; D J Burks; D Withers; J C Bruning; C R Kahn; M F White; D Accili
Journal:  J Clin Invest       Date:  2000-01       Impact factor: 14.808

6.  Linkage of type 2 diabetes mellitus and of age at onset to a genetic location on chromosome 10q in Mexican Americans.

Authors:  R Duggirala; J Blangero; L Almasy; T D Dyer; K L Williams; R J Leach; P O'Connell; M P Stern
Journal:  Am J Hum Genet       Date:  1999-04       Impact factor: 11.025

7.  Glycogen synthase activity is reduced in cultured skeletal muscle cells of non-insulin-dependent diabetes mellitus subjects. Biochemical and molecular mechanisms.

Authors:  R R Henry; T P Ciaraldi; L Abrams-Carter; S Mudaliar; K S Park; S E Nikoulina
Journal:  J Clin Invest       Date:  1996-09-01       Impact factor: 14.808

8.  A large sample of finnish diabetic sib-pairs reveals no evidence for a non-insulin-dependent diabetes mellitus susceptibility locus at 2qter.

Authors:  S Ghosh; E R Hauser; V L Magnuson; T Valle; D S Ally; Z E Karanjawala; J B Rayman; J I Knapp; A Musick; J Tannenbaum; C Te; W Eldridge; S Shapiro; T Musick; C Martin; A So; A Witt; J B Harvan; R M Watanabe; W Hagopian; J Eriksson; S J Nylund; K Kohtamaki; E Tuomilehto-Wolf; M Boehnke
Journal:  J Clin Invest       Date:  1998-08-15       Impact factor: 14.808

9.  Type 2 Diabetes Genetics: Beyond GWAS.

Authors:  Dharambir K Sanghera; Piers R Blackett
Journal:  J Diabetes Metab       Date:  2012-06-23

10.  Evidence for a genetic basis for hyperandrogenemia in polycystic ovary syndrome.

Authors:  R S Legro; D Driscoll; J F Strauss; J Fox; A Dunaif
Journal:  Proc Natl Acad Sci U S A       Date:  1998-12-08       Impact factor: 11.205
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.