Malaria therapy and prophylaxis with cotrifazid, a multiple complex combination consisting of rifampicin + isoniazid + sulfamethoxazole + trimethoprim.

This report contains the first therapeutic results with the multiple combination rifampicin + isoniazid + sulfamethoxazole + trimethoprim in the treatment of malaria. Clinical symptoms declined rapidly and parasites were cleared from the erythrocytes. Tolerance was excellent. This fixed combination is outstandingly practicable, with few problems with compliance.