Literature DB >> 852173

The stimulation of lymphocytes by nucleus pulposus in patients with degenerative disk disease of the lumbar spine.

S D Gertzbein, J H Tait, S R Devlin.   

Abstract

Being avascular the nucleus pulposus is not normally in contact with the immune mechanisms. Rupture out of its confines may result in an inflammatory reaction and contact with immunocompetent cells. Using the lymphocyte transformation test we incubated lymphocytes of 25 patients and 43 controls with an extract of nucleus pulposus. Ten patients with sequestrated or large herniated disks had a mean transformation index of 16.6 compared to controls whose mean index was 3.6. Nine patients with negative myelograms had an idex similar to controls. These results suggest an auto-immune response to nucleus pulposus in patients with sequestrated disks.

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Mesh：

Year:  1977        PMID： 852173

Source DB:  PubMed          Journal:  Clin Orthop Relat Res        ISSN： 0009-921X            Impact factor:   4.176


  14 in total

Review 1.  Immune cascades in human intervertebral disc: the pros and cons.

Authors:  Zhen Sun; Ming Zhang; Xu-Hong Zhao; Zhi-Heng Liu; Yang Gao; Dino Samartzis; Hai-Qiang Wang; Zhuo-Jing Luo
Journal:  Int J Clin Exp Pathol       Date:  2013-05-15

Review 2.  Pathobiology of Modic changes.

Authors:  Stefan Dudli; Aaron J Fields; Dino Samartzis; Jaro Karppinen; Jeffrey C Lotz
Journal:  Eur Spine J       Date:  2016-02-25       Impact factor: 3.134

3.  Plasmacytoid dendritic cells and memory T cells infiltrate true sequestrations stronger than subligamentous sequestrations: evidence from flow cytometric analysis of disc infiltrates.

Authors:  Andrea Geiss; Rolf Sobottke; Karl Stefan Delank; Peer Eysel
Journal:  Eur Spine J       Date:  2016-02-23       Impact factor: 3.134

4.  Mineralocorticoid receptor blocker eplerenone reduces pain behaviors in vivo and decreases excitability in small-diameter sensory neurons from local inflamed dorsal root ganglia in vitro.

Authors:  Fei Dong; Wenrui Xie; Judith A Strong; Jun-Ming Zhang
Journal:  Anesthesiology       Date:  2012-11       Impact factor: 7.892

5.  Robust increase of cutaneous sensitivity, cytokine production and sympathetic sprouting in rats with localized inflammatory irritation of the spinal ganglia.

Authors:  W-R Xie; H Deng; H Li; T L Bowen; J A Strong; J-M Zhang
Journal:  Neuroscience       Date:  2006-08-02       Impact factor: 3.590

6.  Heberden Society: combined meeting, July 1979.

Authors: 
Journal:  Ann Rheum Dis       Date:  1979-12       Impact factor: 19.103

7.  Autoimmunity and the prolapsed intervertebral disc syndrome.

Authors:  M de Silva; B L Hazleman; M Ward; J R Park; I Dickson
Journal:  Rheumatol Int       Date:  1981       Impact factor: 2.631

8.  Transforaminal epidural Etanercept for the treatment of prolapsed lumbar intervertebral disc induced sciatica.

Authors:  Ashish Dagar; Ramesh Kumar; Abhishek Kashyap; Vinay Prabhat; Hitesh Lal; Lalit Kumar
Journal:  J Clin Orthop Trauma       Date:  2016-10-25

9.  Autoimmunity and chondrolysis of the hip. A report of two cases.

Authors:  Y Yoshioka; K Shichikawa
Journal:  Int Orthop       Date:  1987       Impact factor: 3.075

10.  Key role of CCR2-expressing macrophages in a mouse model of low back pain and radiculopathy.

Authors:  Li Zhang; Wenrui Xie; Jingdong Zhang; Hailey Shanahan; Raquel Tonello; Sang Hoon Lee; Judith A Strong; Temugin Berta; Jun-Ming Zhang
Journal:  Brain Behav Immun       Date:  2020-11-14       Impact factor: 7.217
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