| Literature DB >> 8521716 |
Z Gu1, P Zhu, H Luo, X Zhu, G Zhang, S Wu.
Abstract
The endometrium was studied by morphometry in 34 healthy women before and after one year's use of an IUD releasing levonorgestrel at a rate 20 micrograms/24 hr (LNG-IUD-20). The effect was compared with that of an IUD releasing 2 micrograms levonorgestrel/24 hr (LNG-IUD-2). The appearance of suppressed endometrial proliferative activity and increased inflammatory reaction was similar in the two experimental groups, suggesting that the morphological alterations were independent of the LNG dosage. The result of this study, combined with clinical data, suggests that LNG-IUD-20 could replace LNG-IUD-2 without any additional side effects. The efficacy of LNG-IUD-20 is also likely to last for a longer period than the LNG-IUD-2.Entities:
Keywords: Asia; Biology; Case Control Studies; China; Contraception; Contraceptive Agents; Contraceptive Agents, Female; Contraceptive Agents, Progestin; Contraceptive Methods; Developing Countries; Eastern Asia; Endometrial Effects; Endometrium; Family Planning; Genitalia; Genitalia, Female; Histology; Iud; Iud, Hormone Releasing; Levonorgestrel; Physiology; Research Methodology; Research Report; Studies; Urogenital System; Uterus
Mesh：
Substances：
Year: 1995 PMID： 8521716 DOI： 10.1016/0010-7824(95)00125-t
Source DB: PubMed Journal: Contraception ISSN： 0010-7824 Impact factor: 3.375