Literature DB >> 8521448

Redirection of cellular cytotoxicity. A two-step approach using recombinant single-chain Fv molecules.

A J George1, J A Titus, C R Jost, I Kurucz, P Perez, S M Andrew, P J Nicholls, J S Huston, D M Segal.   

Abstract

In this article the authors discuss an indirect system for redirecting cellular cytotoxicity, which utilizes a "universal" bispecific antibody to redirect T-cells to kill cells targeted with single-chain Fv (sFv) fusion proteins that carry a peptide tag recognized by the bispecific antibody. This approach has a number of theoretical advantages in the immunotherapy of cancer.

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Year:  1995        PMID： 8521448     DOI： 10.1007/bf02791577

Source DB:  PubMed          Journal:  Cell Biophys        ISSN： 0163-4992


  33 in total

1.  Multi-subunit proteins on the surface of filamentous phage: methodologies for displaying antibody (Fab) heavy and light chains.

Authors:  H R Hoogenboom; A D Griffiths; K S Johnson; D J Chiswell; P Hudson; G Winter
Journal:  Nucleic Acids Res       Date:  1991-08-11       Impact factor: 16.971

2.  Rapid tumor penetration of a single-chain Fv and comparison with other immunoglobulin forms.

Authors:  T Yokota; D E Milenic; M Whitlow; J Schlom
Journal:  Cancer Res       Date:  1992-06-15       Impact factor: 12.701

3.  Redirection of T cell-mediated cytotoxicity by a recombinant single-chain Fv molecule.

Authors:  A J George; J A Titus; C R Jost; I Kurucz; P Perez; S M Andrew; P J Nicholls; J S Huston; D M Segal
Journal:  J Immunol       Date:  1994-02-15       Impact factor: 5.422

4.  Protein engineering of antibody binding sites: recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coli.

Authors:  J S Huston; D Levinson; M Mudgett-Hunter; M S Tai; J Novotný; M N Margolies; R J Ridge; R E Bruccoleri; E Haber; R Crea
Journal:  Proc Natl Acad Sci U S A       Date:  1988-08       Impact factor: 11.205

5.  Human T cells targeted with anti-T3 cross-linked to antitumor antibody prevent tumor growth in nude mice.

Authors:  J A Titus; M A Garrido; T T Hecht; D F Winkler; J R Wunderlich; D M Segal
Journal:  J Immunol       Date:  1987-06-01       Impact factor: 5.422

6.  Quantitative and qualitative aspects of radiolocalization in colon cancer patients of intravenously administered MAb B72.3.

Authors:  J M Esteban; D Colcher; P Sugarbaker; J A Carrasquillo; G Bryant; A Thor; J C Reynolds; S M Larson; J Schlom
Journal:  Int J Cancer       Date:  1987-01-15       Impact factor: 7.396

7.  Three-step monoclonal antibody tumor targeting in carcinoembryonic antigen-positive patients.

Authors:  G Paganelli; P Magnani; F Zito; E Villa; F Sudati; L Lopalco; C Rossetti; M Malcovati; F Chiolerio; E Seccamani
Journal:  Cancer Res       Date:  1991-11-01       Impact factor: 12.701

8.  Miniantibodies: use of amphipathic helices to produce functional, flexibly linked dimeric FV fragments with high avidity in Escherichia coli.

Authors:  P Pack; A Plückthun
Journal:  Biochemistry       Date:  1992-02-18       Impact factor: 3.162

9.  Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product.

Authors:  G I Evan; G K Lewis; G Ramsay; J M Bishop
Journal:  Mol Cell Biol       Date:  1985-12       Impact factor: 4.272

10.  Characterization of single-chain antibody (sFv)-toxin fusion proteins produced in vitro in rabbit reticulocyte lysate.

Authors:  P J Nicholls; V G Johnson; S M Andrew; H R Hoogenboom; J C Raus; R J Youle
Journal:  J Biol Chem       Date:  1993-03-05       Impact factor: 5.486
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