Literature DB >> 8520460

Synaptic like microvesicles: do they participate in regulated exocytosis?

I Llona1.   

Abstract

Synaptic like microvesicles (SLMV) form a pleiomorphic population of vesicles present in neuroendocrine cells of the pituitary and the adrenal medulla. Their composition and biogenesis is very similar to small synaptic vesicles (SSV) present in nerve terminals. Membrane proteins of SSV involved in fusion (synaptotagmin) and trafficking (Rab 3) together with synaptophysin have been identified on SLMV. The SLMV from pancreatic beta cells store GABA, those present in chromaffin cells catecholamines and/or acetylcholine. We conclude that SLMV may participate in regulated exocytosis based on (a) their localization near release sites, (b) their content and (c) their membrane composition. The functional meaning and the way this process is regulated remain to be elucidated.

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Year:  1995        PMID： 8520460     DOI： 10.1016/0197-0186(95)00005-s

Source DB:  PubMed          Journal:  Neurochem Int        ISSN： 0197-0186            Impact factor:   3.921


  8 in total

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4.  Ultrastructural organization of bovine chromaffin cell cortex-analysis by cryofixation and morphometry of aspects pertinent to exocytosis.

Authors:  H Plattner; A R Artalejo; E Neher
Journal:  J Cell Biol       Date:  1997-12-29       Impact factor: 10.539

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Review 7.  Alpha7 nicotinic acetylcholine receptor is a target in pharmacology and toxicology.

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Journal:  Int J Mol Sci       Date:  2012-02-17       Impact factor: 6.208

8.  Visualizing subcellular rearrangements in intact β cells using soft x-ray tomography.

Authors:  Kate L White; Jitin Singla; Valentina Loconte; Jian-Hua Chen; Axel Ekman; Liping Sun; Xianjun Zhang; John Paul Francis; Angdi Li; Wen Lin; Kaylee Tseng; Gerry McDermott; Frank Alber; Andrej Sali; Carolyn Larabell; Raymond C Stevens
Journal:  Sci Adv       Date:  2020-12-09       Impact factor: 14.136
  8 in total

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