Literature DB >> 8519278

In vitro binding of a novel dopamine D3 receptor ligand: [125I]trans-7-OH-PIPAT-A.

M P Kung1, H F Kung, S Chumpradit, C Foulon.   

Abstract

An iodinated dopamine D3 receptor ligand, [125I]trans-7-OH-PIPAT-A-trans-7-hydroxy-2-(N-n-propyl-N-3'-iodo-2 '- propenyl)aminotetralin, was developed. This ligand demonstrated unique high affinity and selectivity toward the dopamine D3 receptor; Kd = 0.48 nM and Bmax = 240 fmol/mg of protein in rat striatal membrane homogenates.

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Year:  1993        PMID： 8519278     DOI： 10.1016/0014-2999(93)90839-a

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  3 in total

1.  Endogenous dopamine limits the binding of antipsychotic drugs to D3 receptors in the rat brain: a quantitative autoradiographic study.

Authors:  A Schotte; P F Janssen; P Bonaventure; J E Leysen
Journal:  Histochem J       Date:  1996-11

2.  Selective overexpression of dopamine D3 receptors in the striatum disrupts motivation but not cognition.

Authors:  Eleanor H Simpson; Vanessa Winiger; Dominik K Biezonski; Iram Haq; Eric R Kandel; Christoph Kellendonk
Journal:  Biol Psychiatry       Date:  2013-12-05       Impact factor: 13.382

3.  Characterization of binding sites for [125I]R(+)trans-7-OH-PIPAT in rat brain.

Authors:  M P Kung; S Chumpradit; D Frederick; S Garner; K D Burris; P B Molinoff; H F Kung
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1994-12       Impact factor: 3.000
  3 in total

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