Literature DB >> 8518406

Epidermal growth factor receptor and prognosis in human breast cancer: a prospective study.

P G Koenders1, L V Beex, C B Kienhuis, P W Kloppenborg, T J Benraad.   

Abstract

The prognostic value of Epidermal Growth Factor Receptor (EGFR) in human breast cancer is a matter of debate. We conducted a prospective study that included 459 unselected patients with primary breast cancer (median follow-up 24 months) to assess the prognostic value of EGFR. EGFR was assessed using a standardized radioligand binding assay. Univariate analysis showed that EGFR is a factor indicative of a poor prognosis with respect to Disease Free Survival (DFS, P = 0.03) and Overall Survival (OS, P = 0.002), if an EGFR level of 50 fmol/mg of membrane protein is introduced as a cut-off for EGFR-positivity. Multivariate analysis showed that EGFR was not an independent factor. This prospective study shows that EGFR, although not an independent factor, is indicative of poor prognosis in human breast cancer.

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Year:  1993        PMID： 8518406     DOI： 10.1007/BF00662397

Source DB:  PubMed          Journal:  Breast Cancer Res Treat        ISSN： 0167-6806            Impact factor:   4.872


  18 in total

1.  Revision of the standards for the assessment of hormone receptors in human breast cancer; report of the second E.O.R.T.C. Workshop, held on 16-17 March, 1979, in the Netherlands Cancer Institute.

Authors: 
Journal:  Eur J Cancer       Date:  1980-11       Impact factor: 9.162

2.  Epidermal growth factor receptors and prognosis in primary breast cancer.

Authors:  F Spyratos; J C Delarue; C Andrieu; R Lidereau; M H Champème; K Hacène; M Brunet
Journal:  Breast Cancer Res Treat       Date:  1990-12       Impact factor: 4.872

3.  Prognostic value of receptors for insulin-like growth factor 1, somatostatin, and epidermal growth factor in human breast cancer.

Authors:  J A Foekens; H Portengen; W L van Putten; A M Trapman; J C Reubi; J Alexieva-Figusch; J G Klijn
Journal:  Cancer Res       Date:  1989-12-15       Impact factor: 12.701

4.  Disease-free interval and estrogen receptor activity in tumor tissue of patients with primary breast cancer: analysis after long-term follow-up.

Authors:  J M Raemaekers; L V Beex; A J Koenders; G F Pieters; A G Smals; T J Benraad; P W Kloppenborg
Journal:  Breast Cancer Res Treat       Date:  1985       Impact factor: 4.872

5.  Growth factor expression in breast tissue.

Authors:  R C Coombes; P Barrett-Lee; Y Luqmani
Journal:  J Steroid Biochem Mol Biol       Date:  1990-12-20       Impact factor: 4.292

6.  Prognostic significance of the receptor for epidermal growth factor in human mammary carcinomas.

Authors:  A Macias; E Azavedo; T Hägerström; C Klintenberg; R Pérez; L Skoog
Journal:  Anticancer Res       Date:  1987 May-Jun       Impact factor: 2.480

7.  Human breast cancer: survival from first metastasis. Breast Cancer Study Group.

Authors:  P G Koenders; L V Beex; P W Kloppenborg; A G Smals; T J Benraad
Journal:  Breast Cancer Res Treat       Date:  1992       Impact factor: 4.872

8.  Receptors for epidermal growth factor and estrogen as predictors of relapse in patients with mammary carcinoma.

Authors:  M A Ríos; A Macías; R Pérez; A Lage; L Skoog
Journal:  Anticancer Res       Date:  1988 Jan-Feb       Impact factor: 2.480

Review 9.  The clinical significance of epidermal growth factor receptor (EGF-R) in human breast cancer: a review on 5232 patients.

Authors:  J G Klijn; P M Berns; P I Schmitz; J A Foekens
Journal:  Endocr Rev       Date:  1992-02       Impact factor: 19.871

10.  Epidermal growth factor receptor expression as a prognostic indicator in breast cancer.

Authors:  M Toi; A Osaki; H Yamada; T Toge
Journal:  Eur J Cancer       Date:  1991       Impact factor: 9.162
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  14 in total

1.  Biological indices in the assessment of breast cancer.

Authors:  A S Leong; A K Lee
Journal:  Clin Mol Pathol       Date:  1995-10

2.  Combined caveolin-1 and epidermal growth factor receptor expression as a prognostic marker for breast cancer.

Authors:  Ya-Nan Liang; Yu Liu; Letian Wang; Guodong Yao; Xiaobo Li; Xiangning Meng; Fan Wang; Ming Li; Dandan Tong; Jingshu Geng
Journal:  Oncol Lett       Date:  2018-04-18       Impact factor: 2.967

Review 3.  The epidermal growth factor receptor in breast cancer.

Authors:  S B Fox; A L Harris
Journal:  J Mammary Gland Biol Neoplasia       Date:  1997-04       Impact factor: 2.673

4.  Somatic deletions of the polyA tract in the 3' untranslated region of epidermal growth factor receptor are common in microsatellite instability-high endometrial and colorectal carcinomas.

Authors:  Ma Deqin; Zhao Chen; Christopher Nero; Keyur P Patel; Emad M Daoud; Hanyin Cheng; Bojana Djordjevic; Russell R Broaddus; L Jeffrey Medeiros; Asif Rashid; Rajyalakshmi Luthra
Journal:  Arch Pathol Lab Med       Date:  2012-05       Impact factor: 5.534

5.  The prognostic significance of epidermal growth factor receptor expression in breast cancer.

Authors:  M Noguchi; Y Mizukami; K Kinoshita; M Earashi; M Thomas; I Miyazaki
Journal:  Surg Today       Date:  1994       Impact factor: 2.549

6.  Lack of prognostic value of epidermal growth factor receptor in a series of 229 T1/T2, N0/N1 breast cancers, with well defined prognostic parameters.

Authors:  M Bolla; M Chedin; M Colonna; J Marron-Charrière; B Rostaing-Puissant; D Pasquier; M H Panh; P Winckel; E M Chambaz
Journal:  Breast Cancer Res Treat       Date:  1994       Impact factor: 4.872

Review 7.  The EGF receptor family--multiple roles in proliferation, differentiation, and neoplasia with an emphasis on HER4.

Authors:  H Shelton Earp; Benjamin F Calvo; Carolyn I Sartor
Journal:  Trans Am Clin Climatol Assoc       Date:  2003

Review 8.  EGF receptor expression, regulation, and function in breast cancer.

Authors:  S A Chrysogelos; R B Dickson
Journal:  Breast Cancer Res Treat       Date:  1994-01       Impact factor: 4.872

9.  The epidermal growth factor receptor as a prognostic marker: results of 370 patients and review of 3009 patients.

Authors:  S B Fox; K Smith; J Hollyer; M Greenall; D Hastrich; A L Harris
Journal:  Breast Cancer Res Treat       Date:  1994-01       Impact factor: 4.872

10.  Epidermal growth factor receptor-mediated membrane type 1 matrix metalloproteinase endocytosis regulates the transition between invasive versus expansive growth of ovarian carcinoma cells in three-dimensional collagen.

Authors:  Natalie M Moss; Yueying Liu; Jeff J Johnson; Philip Debiase; Jonathan Jones; Laurie G Hudson; Hidayatullah G Munshi; M Sharon Stack
Journal:  Mol Cancer Res       Date:  2009-06-09       Impact factor: 5.852
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