Literature DB >> 8518183

A unique case of t(15;17) acute promyelocytic leukaemia (M3) developing into acute myeloblastic leukaemia (M1) with t(7;21) at relapse.

T Jubashi1, K Nagai, Y Miyazaki, H Nakamura, T Matsuo, K Kuriyama, M Tomonaga.   

Abstract

This report describes a case of t(15;17) acute promyelcytic leukaemia (APL, FAB subtype M3) with dysgranulopoiesis at diagnosis in a patient who developed myelodysplasia (MDS) and then a second phenotype of t(7;21) acute myeloblastic leukaemia (AML, FAB subtype M1) at the time of relapse. To our knowledge, there is no report of a second phenotype of AML occurring after complete remission (CR) of APL. Furthermore, this is the first report of chromosomal abnormality t(7;21) in a case of AML. Several hypotheses for this unusual course of APL are discussed.

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Year:  1993        PMID： 8518183     DOI： 10.1111/j.1365-2141.1993.tb04709.x

Source DB:  PubMed          Journal:  Br J Haematol        ISSN： 0007-1048            Impact factor:   6.998


  6 in total

1.  Two independent clones in myelodysplastic syndrome following treatment of acute myeloid leukemia.

Authors:  Masahiro Masuya; Naoyuki Katayama; Koichi Inagaki; Hiroshi Miwa; Natsuki Hoshino; Hiroyuki Miyashita; Hirohito Suzuki; Hiroto Araki; Hidetsugu Mitani; Kazuhiro Nishii; Shin-ichi Kageyama; Nobuyuki Minami; Hiroshi Shiku
Journal:  Int J Hematol       Date:  2002-02       Impact factor: 2.490

2.  Clinical and laboratory features of seven patients with acute myeloid leukemia (AML)-M2/M3 and elevated myeloblasts and abnormal promyelocytes.

Authors:  GanLin He; ChunYan Wang; QingEn Li; Huo Tan; FuXiong Chen; ZhenQian Huang; BaoDan Yu; LiXia Zheng; RunHui Zheng; Dan Liu
Journal:  Cancer Cell Int       Date:  2014-12-31       Impact factor: 5.722

3.  Acute promyelocytic leukemia relapsing into acute myeloid leukemia-M2 with normal cytogenetics.

Authors:  Ranjit Kumar Sahoo; Lalit Kumar; Rajive Kumar; Atul Sharma
Journal:  Indian J Med Paediatr Oncol       Date:  2013-10

4.  [Therapy-related myeloid neoplasms after successful treatment for acute promyelocytic leukemia: a report of four cases and literature review].

Authors:  Z Wang; M Z Xu; Y F Chen; F Xue; L Zhang; Y M Hu; C W Li; S Z Li; J X Wang; Y C Mi
Journal:  Zhonghua Xue Ye Xue Za Zhi       Date:  2019-12-14

5.  A case of therapy-related acute myeloid leukemia with a normal karyotype after sustained molecular complete remission of acute promyelocytic leukemia.

Authors:  Sang Hyuk Park; Hyun-Sook Chi; Young-Uk Cho; Seongsoo Jang; Chan-Jeoung Park; Je-Hwan Lee
Journal:  Ann Lab Med       Date:  2013-12-06       Impact factor: 3.464

6.  Secondary clonal hematologic neoplasia following successful therapy for acute promyelocytic leukemia (APL): A report of two cases and review of the literature.

Authors:  Daria Gaut; Joshua Sasine; Gary Schiller
Journal:  Leuk Res Rep       Date:  2018-04-16
  6 in total

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