Literature DB >> 8517641

Immunochemotherapy prevents human colon cancer metastasis after orthotopic onplantation of histologically-intact tumor tissue in nude mice.

T Furukawa1, T Kubota, M Watanabe, T H Kuo, S Kase, Y Saikawa, H Tanino, T Teramoto, K Ishibiki, M Kitajima.   

Abstract

A metastatic model of human colon cancer has been previously established using orthotopic onplantation of histologically intact in tissue nude mice. In this study, effects of immunochemotherapy using OK-432, 5-fluorouracil (5-FU) and mitomycin C (MMC) on Col-2-JCK, a human colon cancer xenograft, were evaluated using this model. When 5-FU and MMC were administered without OK-432, liver metastases were not reduced even at maximum tolerated doses of both drugs, although cecal tumor growth was significantly reduced. On the other hand, when combined with OK-432, both 5-FU and MMC reduced liver metastases with synergistic reduction of cecal tumor growth, demonstrating the potential of combining immunotherapy with chemotherapy against metastases.

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Year:  1993        PMID： 8517641

Source DB:  PubMed          Journal:  Anticancer Res        ISSN： 0250-7005            Impact factor:   2.480


  6 in total

Review 1.  Orthotopic metastatic mouse models for anticancer drug discovery and evaluation: a bridge to the clinic.

Authors:  R M Hoffman
Journal:  Invest New Drugs       Date:  1999       Impact factor: 3.850

2.  Overview of human primary tumorgraft models: comparisons with traditional oncology preclinical models and the clinical relevance and utility of primary tumorgrafts in basic and translational oncology research.

Authors:  David H Lum; Cindy Matsen; Alana L Welm; Bryan E Welm
Journal:  Curr Protoc Pharmacol       Date:  2012-12

3.  Successful fluorescence-guided surgery on human colon cancer patient-derived orthotopic xenograft mouse models using a fluorophore-conjugated anti-CEA antibody and a portable imaging system.

Authors:  Yukihiko Hiroshima; Ali Maawy; Cristina A Metildi; Yong Zhang; Fuminari Uehara; Shinji Miwa; Shuya Yano; Sho Sato; Takashi Murakami; Masashi Momiyama; Takashi Chishima; Kuniya Tanaka; Michael Bouvet; Itaru Endo; Robert M Hoffman
Journal:  J Laparoendosc Adv Surg Tech A       Date:  2014-02-04       Impact factor: 1.878

4.  Hand-held high-resolution fluorescence imaging system for fluorescence-guided surgery of patient and cell-line pancreatic tumors growing orthotopically in nude mice.

Authors:  Yukihiko Hiroshima; Ali Maawy; Sho Sato; Takashi Murakami; Fuminari Uehara; Shinji Miwa; Shuya Yano; Masashi Momiyama; Takashi Chishima; Kuniya Tanaka; Michael Bouvet; Itaru Endo; Robert M Hoffman
Journal:  J Surg Res       Date:  2013-11-19       Impact factor: 2.192

5.  Liver colonization competence governs colon cancer metastasis.

Authors:  T H Kuo; T Kubota; M Watanabe; T Furukawa; T Teramoto; K Ishibiki; M Kitajima; A R Moossa; S Penman; R M Hoffman
Journal:  Proc Natl Acad Sci U S A       Date:  1995-12-19       Impact factor: 11.205

6.  Hybrid liposomes showing enhanced accumulation in tumors as theranostic agents in the orthotopic graft model mouse of colorectal cancer.

Authors:  Masaki Okumura; Hideaki Ichihara; Yoko Matsumoto
Journal:  Drug Deliv       Date:  2018-11       Impact factor: 6.419
  6 in total

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