Literature DB >> 8516849

The multistep nature of cancer.

B Vogelstein1, K W Kinzler.   

Abstract

Cancer is a distinct type of genetic disease in which not one, but several, mutations are required. Each mutation drives a wave of cellular multiplication associated with gradual increases in tumor size, disorganization and malignancy. Three to six such mutations appear to be required to complete this process.

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Year:  1993        PMID： 8516849     DOI： 10.1016/0168-9525(93)90209-z

Source DB:  PubMed          Journal:  Trends Genet        ISSN： 0168-9525            Impact factor:   11.639


  387 in total

1.  Changing roles of cadherins and catenins during progression of squamous intraepithelial lesions in the uterine cervix.

Authors:  C J de Boer; E van Dorst; H van Krieken; C M Jansen-van Rhijn; S O Warnaar; G J Fleuren; S V Litvinov
Journal:  Am J Pathol       Date:  1999-08       Impact factor: 4.307

2.  Malignant fibrous histiocytomas and H-ras-1 oncogene point mutations.

Authors:  P Rieske; J Bartkowiak; A Szadowska; M Debiec-Rychter
Journal:  Mol Pathol       Date:  1999-04

Review 3.  Soft tissue sarcomas and p53 mutations.

Authors:  H Taubert; A Meye; P Würl
Journal:  Mol Med       Date:  1998-06       Impact factor: 6.354

4.  Growth inhibition of human glioma cells by transfection-induced P21 and its effects on telomerase activity.

Authors:  K Harada; K Kurisu; T Sadatomo; H Tahara; E Tahara; T Ide; E Tahara
Journal:  J Neurooncol       Date:  2000-03       Impact factor: 4.130

5.  Restricted 12p amplification and RAS mutation in human germ cell tumors of the adult testis.

Authors:  H Roelofs; M C Mostert; K Pompe; G Zafarana; M van Oorschot; R J van Gurp; A J Gillis; H Stoop; B Beverloo; J W Oosterhuis; C Bokemeyer; L H Looijenga
Journal:  Am J Pathol       Date:  2000-10       Impact factor: 4.307

6.  Gross chromosomal rearrangements and genetic exchange between nonhomologous chromosomes following BRCA2 inactivation.

Authors:  V P Yu; M Koehler; C Steinlein; M Schmid; L A Hanakahi; A J van Gool; S C West; A R Venkitaraman
Journal:  Genes Dev       Date:  2000-06-01       Impact factor: 11.361

7.  p53-independent inhibition of proliferation and p21(WAF1/Cip1)-modulated induction of cell death by the antioxidants N-acetylcysteine and vitamin E.

Authors:  J L Nargi; R R Ratan; D E Griffin
Journal:  Neoplasia       Date:  1999-12       Impact factor: 5.715

8.  Igf1r as a therapeutic target in a mouse model of basal-like breast cancer.

Authors:  Apostolos Klinakis; Matthias Szabolcs; Guoying Chen; Shouhong Xuan; Hanina Hibshoosh; Argiris Efstratiadis
Journal:  Proc Natl Acad Sci U S A       Date:  2009-01-27       Impact factor: 11.205

9.  Expressions of two adenomatous polyposis coli and E-cadherin proteins on human colorectal cancers.

Authors:  Koh Furuta; Shingo Yoshioka; Satoko Okabe; Masato Ikeda; Mihoko Oginosawa; Seiyo Ikeda; Yoshifuku Nakayama; Masahiro Kikuchi; Stanley R Hamilton
Journal:  Virchows Arch       Date:  2003-02-11       Impact factor: 4.064

10.  Assessing intratumor heterogeneity and tracking longitudinal and spatial clonal evolutionary history by next-generation sequencing.

Authors:  Yuchao Jiang; Yu Qiu; Andy J Minn; Nancy R Zhang
Journal:  Proc Natl Acad Sci U S A       Date:  2016-08-29       Impact factor: 11.205
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