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Literature DB >> 8516845

Genomic structure and function in the MHC.

Abstract

The major histocompatibility complex (MHC) is a fascinating region of the human genome. More is known about this 4 Mb of DNA (0.1% of the genome) on the short arm of chromosome 6 than about any other region of similar size. Among the 80 or so MHC genes found so far are several clusters with related functions in antigen processing and presentation. In addition to its importance in immunology, the MHC is a useful model for investigating gene organization, polymorphism, linkage disequilibrium and recombination. A large number of diseases, many of the autoimmune type, are associated with the region.

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Year: 1993 PMID： 8516845 DOI： 10.1016/0168-9525(93)90205-v

Source DB: PubMed Journal: Trends Genet ISSN： 0168-9525 Impact factor: 11.639

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Cited

36 in total

1. Expression of the three human major histocompatibility complex class II isotypes exhibits a differential dependence on the transcription factor RFXAP.

Authors: M Peretti; J Villard; E Barras; M Zufferey; W Reith
Journal: Mol Cell Biol Date: 2001-09 Impact factor: 4.272

9. Construction of a genomic DNA 'feature map' by sequencing from nested deletions: application to the HLA class I region.

Authors: B R Krishnan; I Jamry; D E Berg; C M Berg; D D Chaplin
Journal: Nucleic Acids Res Date: 1995-01-11 Impact factor: 16.971

10. Flanking p10 contribution and sequence bias in matrix based epitope prediction: revisiting the assumption of independent binding pockets.

Authors: Christian S Parry
Journal: BMC Struct Biol Date: 2008-10-16

Genomic structure and function in the MHC.

1. Expression of the three human major histocompatibility complex class II isotypes exhibits a differential dependence on the transcription factor RFXAP.

Review 2. Novel mechanisms of class II major histocompatibility complex gene regulation.

3. Relation of a TNF gene polymorphism to severe sepsis in trauma patients.

4. The major resistance gene cluster in lettuce is highly duplicated and spans several megabases.

5. The mouse H-2A region influences the envelope gene structure of tumor-associated murine leukemia viruses.

6. A new non-HLA multigene family associated with the PERB11 family within the MHC class I region.

7. Identification of seven new human MHC class I region genes around the HLA-F locus.

Review 8. Biological Consequences of MHC-II Expression by Tumor Cells in Cancer.

9. Construction of a genomic DNA 'feature map' by sequencing from nested deletions: application to the HLA class I region.

10. Flanking p10 contribution and sequence bias in matrix based epitope prediction: revisiting the assumption of independent binding pockets.