Literature DB >> 851530

Pyruvate transport in tumour-cell mitochondria.

M L Eboli, G Paradies, T Galeotti, S Papa.   

Abstract

Tumour-cell mitochondria contain a pyruvate-transporting system exhibiting the same general properties as those described in rat liver mitochondria. The Km for net pyruvate uptake in tumour-cell mitochondria is practically similar to that measured in rat liver mitochondria but the V is lower. This difference is also shown by swelling experiments. The possible implication of these observations in the context of lactate accumulation in tumour-cell is discussed.

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Year:  1977        PMID： 851530     DOI： 10.1016/0005-2728(77)90166-9

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  23 in total

Review 1.  Mitochondrial pyruvate transport: a historical perspective and future research directions.

Authors:  Kyle S McCommis; Brian N Finck
Journal:  Biochem J       Date:  2015-03-15       Impact factor: 3.857

2.  [Aerobic glycolysis of tumor cells].

Authors:  F Schneider
Journal:  Naturwissenschaften       Date:  1981-01

3.  A role for the mitochondrial pyruvate carrier as a repressor of the Warburg effect and colon cancer cell growth.

Authors:  John C Schell; Kristofor A Olson; Lei Jiang; Amy J Hawkins; Jonathan G Van Vranken; Jianxin Xie; Robert A Egnatchik; Espen G Earl; Ralph J DeBerardinis; Jared Rutter
Journal:  Mol Cell       Date:  2014-10-21       Impact factor: 17.970

Review 4.  Warburg, me and Hexokinase 2: Multiple discoveries of key molecular events underlying one of cancers' most common phenotypes, the "Warburg Effect", i.e., elevated glycolysis in the presence of oxygen.

Authors:  Peter L Pedersen
Journal:  J Bioenerg Biomembr       Date:  2007-06       Impact factor: 2.945

5.  Polar distribution of sodium-dependent and sodium-independent transport system for L-lactate in the plasma membrane of rat enterocytes.

Authors:  C Storelli; A Corcelli; G Cassano; B Hildmann; H Murer; C Lippe
Journal:  Pflugers Arch       Date:  1980-10       Impact factor: 3.657

6.  Pyruvate dehydrogenase complex of ascites tumour. Activation by AMP and other properties of potential significance in metabolic regulation.

Authors:  P A Lazo; A Sols
Journal:  Biochem J       Date:  1980-09-15       Impact factor: 3.857

7.  Toxic and mutagenic effects of carcinogens on the mitochondria of Saccharomyces cerevisiae.

Authors:  V Egilsson; I H Evans; D Wilkie
Journal:  Mol Gen Genet       Date:  1979-07-02

Review 8.  Mitochondrial pyruvate carrier function and cancer metabolism.

Authors:  Adam J Rauckhorst; Eric B Taylor
Journal:  Curr Opin Genet Dev       Date:  2016-06-05       Impact factor: 5.578

9.  A comparative study of the transport of pyruvate in liver mitochondria from normal and diabetic rats.

Authors:  A Kielducka; G Paradies; S Papa
Journal:  J Bioenerg Biomembr       Date:  1981-08       Impact factor: 2.945

10.  MPC1-like Is a Placental Mammal-specific Mitochondrial Pyruvate Carrier Subunit Expressed in Postmeiotic Male Germ Cells.

Authors:  Benoît Vanderperre; Kristina Cermakova; Jessica Escoffier; Mayis Kaba; Tom Bender; Serge Nef; Jean-Claude Martinou
Journal:  J Biol Chem       Date:  2016-06-17       Impact factor: 5.157
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