Literature DB >> 8513850

Studies on placental transfer of celiprolol.

B Kofahl1, D Henke, A Hettenbach, E Mutschler.   

Abstract

The maternofetal transfer of the beta 1-selective adrenergic antagonist celiprolol has been studied in four hypertensive pregnant women. Fetal plasma concentrations were about 25-50% of the levels found on the maternal side. There was no significant difference between the plasma concentrations of the two enantiomers in the child. Therefore, in further investigations only the racemate needs to be determined.

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Year:  1993        PMID: 8513850     DOI: 10.1007/BF00316477

Source DB:  PubMed          Journal:  Eur J Clin Pharmacol        ISSN: 0031-6970            Impact factor:   2.953


  2 in total

1.  Simultaneous determination of (R)- and (S)-celiprolol in human plasma and urine: high-performance liquid chromatographic assay on a chiral stationary phase with fluorimetric detection.

Authors:  C Hartmann; D Krauss; H Spahn; E Mutschler
Journal:  J Chromatogr       Date:  1989-11-24

2.  Placental transfer of beta-adrenergic antagonists studied in an in vitro perfusion system of human placental tissue.

Authors:  H Schneider; M Proegler
Journal:  Am J Obstet Gynecol       Date:  1988-07       Impact factor: 8.661

  2 in total
  1 in total

Review 1.  Placental transfer of drugs administered to the mother.

Authors:  G M Pacifici; R Nottoli
Journal:  Clin Pharmacokinet       Date:  1995-03       Impact factor: 6.447

  1 in total

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