| Literature DB >> 8513748 |
P B Gichangi1, A O Nyongo, M Temmerman.
Abstract
The relationship between placental characteristics, including weight and inflammation, and pregnancy outcome was examined as part of a case control study looking into the impact of maternal HIV-1 infection on pregnancy outcome. Cases defined as low birth weight (< 2500g) or stillbirth deliveries, were compared to controls defined as mothers who delivered a live born neonate weighing 2500g or more. The mean placental weight and the mean foetal/placental weight ratio were significantly lower in cases (n = 253) than in controls (n = 216) (p < .05). Placental inflammation (chorioamnionitis) was significantly associated with prematurity (p < .001) and with stillbirth (p < .05), maternal HIV-1 antibody being a risk factor for chorioamnionitis in the preterm group. These data support a correlation between placental weight and pregnancy outcome, and suggest that maternal HIV-1 infection is a risk factor for chorioamnionitis in HIV-1 seropositive preterm deliveries.Entities:
Keywords: Africa; Africa South Of The Sahara; Antibodies; Biology; Birth Weight; Body Weight; Case Control Studies; Demographic Factors; Developing Countries; Diseases; Eastern Africa; English Speaking Africa; Fetal Death; Fetal Membranes; Fetus; Hiv Infections; Immunity; Immunologic Factors; Kenya; Low Birth Weight; Mortality; Physiology; Population; Population Dynamics; Pregnancy; Pregnancy Outcomes; Premature Birth; Reproduction; Research Methodology; Research Report; Risk Factors; Studies; Viral Diseases
Mesh：
Year: 1993 PMID： 8513748
Source DB: PubMed Journal: East Afr Med J ISSN： 0012-835X