| Literature DB >> 8513321 |
V C Sheffield1, E M Stone, W L Alward, A V Drack, A T Johnson, L M Streb, B E Nichols.
Abstract
Glaucoma is a significant cause of blindness world wide. There is evidence to suggest that at least a subset of the disease is determined genetically. We studied 37 members of a family affected with an autosomal dominant form of juvenile open angle glaucoma and 22 were found to be affected. Linkage analysis using short tandem repeat markers mapped the disease-causing gene to chromosome 1q21-q31. Eight markers were significantly linked (Zmax > 3.0) to the disease, with the highest lod score 6.5 (theta = 0), provided by D1S212. The atrial natriuretic peptide (ANP)/receptor system has been proposed to have a role in glaucoma and one of the ANP receptor genes maps to chromosome 1q.Entities:
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Year: 1993 PMID： 8513321 DOI： 10.1038/ng0593-47
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330