Literature DB >> 8512533

Quantitative trait loci (QTL) analyses and alcohol-related behaviors.

R Plomin1, G E McClearn.   

Abstract

Recombinant inbred (RI) strains can make an important contribution toward the merger of molecular genetics and quantitative genetics in the quest for quantitative trait loci (QTL). We present preliminary analyses of alcohol-related processes from our ongoing research using the BXD RI series. Issues concerning reliability, genetic correlations, and RI QTL analysis are discussed. Several strategies for replication and extension of QTL candidate regions are considered: F1 crosses between RI strains, F2 crosses, heterogeneous stock, interspecific backcrosses, QTL selection, and the use of murine QTL in chromosomal regions syntenic to human chromosomes as candidate chromosomal regions for human QTL.

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Year:  1993        PMID： 8512533     DOI： 10.1007/BF01067425

Source DB:  PubMed          Journal:  Behav Genet        ISSN： 0001-8244            Impact factor:   2.805


  30 in total

1.  A genetic map of the mouse suitable for typing intraspecific crosses.

Authors:  W Dietrich; H Katz; S E Lincoln; H S Shin; J Friedman; N C Dracopoli; E S Lander
Journal:  Genetics       Date:  1992-06       Impact factor: 4.562

Review 2.  Use of recombinant inbred strains to detect quantitative trait loci associated with behavior.

Authors:  R Plomin; G E McClearn; G Gora-Maslak; J M Neiderhiser
Journal:  Behav Genet       Date:  1991-03       Impact factor: 2.805

Review 3.  Development and applications of a molecular genetic linkage map of the mouse genome.

Authors:  N G Copeland; N A Jenkins
Journal:  Trends Genet       Date:  1991-04       Impact factor: 11.639

4.  D2 dopamine receptor gene is associated but not linked with alcoholism.

Authors:  C R Cloninger
Journal:  JAMA       Date:  1991-10-02       Impact factor: 56.272

Review 5.  The role of inheritance in behavior.

Authors:  R Plomin
Journal:  Science       Date:  1990-04-13       Impact factor: 47.728

6.  Relationship of alcohol dose to intensity of withdrawal signs in mice.

Authors:  D B Goldstein
Journal:  J Pharmacol Exp Ther       Date:  1972-02       Impact factor: 4.030

7.  Recombinant-inbred strains. An aid to finding identity, linkage, and function of histocompatibility and other genes.

Authors:  D W Bailey
Journal:  Transplantation       Date:  1971-03       Impact factor: 4.939

8.  Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction.

Authors:  J L Weber; P E May
Journal:  Am J Hum Genet       Date:  1989-03       Impact factor: 11.025

9.  Alcohol dependence produced in mice by inhalation of ethanol: grading the withdrawal reaction.

Authors:  D B Goldstein; N Pal
Journal:  Science       Date:  1971-04-16       Impact factor: 47.728

10.  Interrelationships of alcohol consumption, actions of alcohol, and biochemical traits.

Authors:  V G Erwin; G E McClearn; A R Kuse
Journal:  Pharmacol Biochem Behav       Date:  1980       Impact factor: 3.533
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  13 in total

1.  Quantitative trait mapping in a diallel cross of recombinant inbred lines.

Authors:  Shirng-Wern Tsaih; Lu Lu; David C Airey; Robert W Williams; Gary A Churchill
Journal:  Mamm Genome       Date:  2005-05       Impact factor: 2.957

2.  QTL influencing baseline hematocrit in the C57BL/6J and DBA/2J lineage: age-related effects.

Authors:  Frank Johannes; David A Blizard; Arimantas Lionikas; Dena H Lang; David J Vandenbergh; Joseph T Stout; James A Strauss; Gerald E McClearn; George P Vogler
Journal:  Mamm Genome       Date:  2006-06-12       Impact factor: 2.957

3.  Quantitative trait loci analysis of structural and material skeletal phenotypes in C57BL/6J and DBA/2 second-generation and recombinant inbred mice.

Authors:  Dean H Lang; Neil A Sharkey; Holly A Mack; George P Vogler; David J Vandenbergh; David A Blizard; Joseph T Stout; Gerald E McClearn
Journal:  J Bone Miner Res       Date:  2004-10-11       Impact factor: 6.741

4.  Genetic and environmental control of variation in retinal ganglion cell number in mice.

Authors:  R W Williams; R C Strom; D S Rice; D Goldowitz
Journal:  J Neurosci       Date:  1996-11-15       Impact factor: 6.167

5.  Quantitative trait loci associated with the behavioral response of B x D recombinant inbred mice to restraint stress: a preliminary communication.

Authors:  B J Tarricone; J N Hingtgen; J K Belknap; S R Mitchell; J I Nurnberger
Journal:  Behav Genet       Date:  1995-09       Impact factor: 2.805

6.  Mapping genes controlling hematocrit in the spontaneously hypertensive rat.

Authors:  M Pravenec; V Zidek; M Zdobinska; V Kren; D Krenova; A Bottger; L F van Zutphen; J Wang; E St Lezin
Journal:  Mamm Genome       Date:  1997-06       Impact factor: 2.957

7.  Genetic analysis of alcohol intake in recombinant inbred and congenic strains derived from A/J and C57BL/6J progenitors.

Authors:  Kathryn Gill; Alan E Boyle
Journal:  Mamm Genome       Date:  2005-05       Impact factor: 2.957

8.  Genetic regulation of gene-specific mRNA by ethanol in vivo and its possible role in ethanol preference in a cross with RI lines in mice.

Authors:  C E Tagliabracci; S M Singh
Journal:  Biochem Genet       Date:  1996-06       Impact factor: 1.890

9.  Evidence for varied aetiologies regulating the transmission of prion disease: implications for understanding the heritable basis of prion incubation times.

Authors:  Conrad O Iyegbe; Oduola O Abiola; Chris Towlson; John F Powell; Steven A Whatley
Journal:  PLoS One       Date:  2010-12-02       Impact factor: 3.240

Review 10.  Quantitative trait loci (QTL) applications to substances of abuse: physical dependence studies with nitrous oxide and ethanol in BXD mice.

Authors:  J K Belknap; P Metten; M L Helms; L A O'Toole; S Angeli-Gade; J C Crabbe; T J Phillips
Journal:  Behav Genet       Date:  1993-03       Impact factor: 2.805
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