OBJECTIVE: To assay the proteolytic activity of plasmin on the vitreoretinal junction and to assess a potential facilitating effect on posterior vitreous detachment. METHODS: We injected 1 U of plasmin into the vitreous of rabbits. Some eyes underwent vitrectomy after plasmin injection. Electroretinography and electron microscopy were performed. RESULTS: In plasmin-treated eyes, electroretinography displayed a transient (3 days) decreased b-wave amplitude. Histologic examination demonstrated posterior vitreous detachment in eyes that received intravitreal plasmin followed by vitrectomy. CONCLUSION: Plasmin may prove to be a useful biochemical adjunct to mechanical vitrectomy.
OBJECTIVE: To assay the proteolytic activity of plasmin on the vitreoretinal junction and to assess a potential facilitating effect on posterior vitreous detachment. METHODS: We injected 1 U of plasmin into the vitreous of rabbits. Some eyes underwent vitrectomy after plasmin injection. Electroretinography and electron microscopy were performed. RESULTS: In plasmin-treated eyes, electroretinography displayed a transient (3 days) decreased b-wave amplitude. Histologic examination demonstrated posterior vitreous detachment in eyes that received intravitreal plasmin followed by vitrectomy. CONCLUSION: Plasmin may prove to be a useful biochemical adjunct to mechanical vitrectomy.
Authors: M Hermel; M Mahgoub; T Youssef; M I Azrak; H Raza; C Alldredge; M Trese; G A Williams; M Hartzer Journal: Graefes Arch Clin Exp Ophthalmol Date: 2005-12-20 Impact factor: 3.117
Authors: M Codenotti; G Maestranzi; U De Benedetto; G Querques; P Della Valle; L Iuliano; G Fogliato; A D'Angelo; F Bandello Journal: Eye (Lond) Date: 2012-12-14 Impact factor: 3.775
Authors: John B Miller; Leo A Kim; David M Wu; Demetrios G Vavvas; Dean Eliott; Deeba Husain Journal: Ophthalmic Surg Lasers Imaging Retina Date: 2014 Jul-Aug Impact factor: 1.300