Literature DB >> 8511586

From RNA to DNA, why so many ribonucleotide reductases?

P Reichard1.   

Abstract

It is generally accepted that DNA appeared after RNA during the chemical evolution of life. To synthesize DNA, deoxyribonucleotides are required as building blocks. At present, these are formed from the corresponding ribonucleotides through the enzymatic action of ribonucleotide reductases. Three classes of enzymes are present in various organisms. There is little sequence similarity among the three classes of reductases. However, enzymic mechanisms and the allosteric behavior of the enzymes from various organisms are strongly conserved, suggesting that the enzymes might have evolved from a common ancestor, with the class III anaerobic Escherichia coli reductase as its closest relative.

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Year:  1993        PMID: 8511586     DOI: 10.1126/science.8511586

Source DB:  PubMed          Journal:  Science        ISSN: 0036-8075            Impact factor:   47.728


  117 in total

1.  High-field EPR detection of a disulfide radical anion in the reduction of cytidine 5'-diphosphate by the E441Q R1 mutant of Escherichia coli ribonucleotide reductase.

Authors:  C C Lawrence; M Bennati; H V Obias; G Bar; R G Griffin; J Stubbe
Journal:  Proc Natl Acad Sci U S A       Date:  1999-08-03       Impact factor: 11.205

2.  Cellular adaptation to down-regulated iron transport into lymphoid leukaemic cells: effects on the expression of the gene for ribonucleotide reductase.

Authors:  C R Chitambar; J P Wereley; T Heiman; W E Antholine; W J O'brien
Journal:  Biochem J       Date:  2000-02-01       Impact factor: 3.857

3.  Identification of ribonucleotide reductase protein R1 as an activator of microtubule nucleation in Xenopus egg mitotic extracts.

Authors:  S Takada; T Shibata; Y Hiraoka; H Masuda
Journal:  Mol Biol Cell       Date:  2000-12       Impact factor: 4.138

4.  Progesterone and DNA damage encourage uterine cell proliferation and decidualization through up-regulating ribonucleotide reductase 2 expression during early pregnancy in mice.

Authors:  Wei Lei; Xu-Hui Feng; Wen-Bo Deng; Hua Ni; Zhi-Rong Zhang; Bo Jia; Xin-Ling Yang; Tong-Song Wang; Ji-Long Liu; Ren-Wei Su; Xiao-Huan Liang; Qian-Rong Qi; Zeng-Ming Yang
Journal:  J Biol Chem       Date:  2012-03-08       Impact factor: 5.157

5.  Ribonucleotide reductase subunit M1 expression in resectable, muscle-invasive urothelial cancer correlates with survival in younger patients.

Authors:  Lauren C Harshman; Gerold Bepler; Zhong Zheng; John P Higgins; Genevera I Allen; Sandy Srinivas
Journal:  BJU Int       Date:  2010-12       Impact factor: 5.588

6.  Hydroxyurea enhances post-fusion hyphal extension during sexual development in C. neoformans var. grubii.

Authors:  M Naim Zulkifli; Jan Naseer Kaur; John C Panepinto
Journal:  Mycopathologia       Date:  2011-09-28       Impact factor: 2.574

7.  Mössbauer properties of the diferric cluster and the differential iron(II)-binding affinity of the iron sites in protein R2 of class Ia Escherichia coli ribonucleotide reductase: a DFT/electrostatics study.

Authors:  Wen-Ge Han; Gregory M Sandala; Debra Ann Giammona; Donald Bashford; Louis Noodleman
Journal:  Dalton Trans       Date:  2011-08-12       Impact factor: 4.390

8.  Apoplastic pH and Fe(3+) reduction in intact sunflower leaves

Authors: 
Journal:  Plant Physiol       Date:  1999-12       Impact factor: 8.340

9.  Isolation of ribonucleotide reductase from Mycobacterium tuberculosis and cloning, expression, and purification of the large subunit.

Authors:  F Yang; G Lu; H Rubin
Journal:  J Bacteriol       Date:  1994-11       Impact factor: 3.490

10.  A second class I ribonucleotide reductase in Enterobacteriaceae: characterization of the Salmonella typhimurium enzyme.

Authors:  A Jordan; E Pontis; M Atta; M Krook; I Gibert; J Barbé; P Reichard
Journal:  Proc Natl Acad Sci U S A       Date:  1994-12-20       Impact factor: 11.205

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