Literature DB >> 8510817

Differential expression of interleukin-6 (IL-6) and interleukin-6 receptor (IL-6R) mRNAs in rat hypothalamus.

R A Gadient1, U Otten.   

Abstract

Using the sensitive technique of reverse transcription followed by polymerase chain reaction (RT-PCR), the expression of interleukin-6 (IL-6) and its receptor (IL-6R) in rat hypothalamus was investigated. Our results show a differential expression of the mRNAs for IL-6 and IL-6R during postnatal development: whereas IL-6 mRNA slightly declines with increasing age, IL-6R mRNA levels markedly increase (4-fold). The time course of these changes correlates with the maturation of the hypothalamo-pituitary-adrenocortical axis, indicating an involvement of the IL-6 system in neuroendocrine regulation. Expression of both genes in other brain areas suggest additional functions in the central nervous system (CNS).

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Year:  1993        PMID： 8510817     DOI： 10.1016/0304-3940(93)90065-s

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


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