Literature DB >> 8510797

Nerve growth factor antibodies recognize neurotrophin-3.

A Negro1, V Corsa, S D Skaper, L Callegaro.   

Abstract

The immunological properties of the neurotrophins NGF, BDNF, and NT-3 were compared using polyclonal and monoclonal antibodies against the beta subunit of mouse NGF. Affinity-purified anti-NGF IgG consistently recognized NGF and NT-3 on Western blots, and inhibited the trophic activity of NGF and NT-3 but not BDNF. In contrast, anti-NGF monoclonal antibodies did not block the trophic activity of either NT-3 or BDNF. These results are consistent with the greater structural overlap between NGF and NT-3 than between NGF and BDNF.

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Year:  1993        PMID： 8510797     DOI： 10.1007/BF00966785

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  29 in total

1.  Primary structure and biological activity of a novel human neurotrophic factor.

Authors:  A Rosenthal; D V Goeddel; T Nguyen; M Lewis; A Shih; G R Laramee; K Nikolics; J W Winslow
Journal:  Neuron       Date:  1990-05       Impact factor: 17.173

2.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

Review 3.  The nerve growth factor 35 years later.

Authors:  R Levi-Montalcini
Journal:  Science       Date:  1987-09-04       Impact factor: 47.728

4.  NT-3, BDNF, and NGF in the developing rat nervous system: parallel as well as reciprocal patterns of expression.

Authors:  P C Maisonpierre; L Belluscio; B Friedman; R F Alderson; S J Wiegand; M E Furth; R M Lindsay; G D Yancopoulos
Journal:  Neuron       Date:  1990-10       Impact factor: 17.173

5.  Purification and characterization of Fab fragments from anti-mouse NGF polyclonal antibodies.

Authors:  L Callegaro; S D Skaper; G Vantini; D Benvegnù; A Di Martino; N Schiavo; C Triban; C Minozzi; A Leon
Journal:  J Mol Recognit       Date:  1990 Oct-Dec       Impact factor: 2.137

Review 6.  The changing scene of neurotrophic factors.

Authors:  H Thoenen
Journal:  Trends Neurosci       Date:  1991-05       Impact factor: 13.837

7.  Neurotrophin-3: a neurotrophic factor related to NGF and BDNF.

Authors:  P C Maisonpierre; L Belluscio; S Squinto; N Y Ip; M E Furth; R M Lindsay; G D Yancopoulos
Journal:  Science       Date:  1990-03-23       Impact factor: 47.728

8.  Three distinct types of monoclonal antibodies after long-term immunization of rats with mouse nerve growth factor.

Authors:  A Cattaneo; B Rapposelli; P Calissano
Journal:  J Neurochem       Date:  1988-04       Impact factor: 5.372

9.  Promotion of central cholinergic and dopaminergic neuron differentiation by brain-derived neurotrophic factor but not neurotrophin 3.

Authors:  B Knüsel; J W Winslow; A Rosenthal; L E Burton; D P Seid; K Nikolics; F Hefti
Journal:  Proc Natl Acad Sci U S A       Date:  1991-02-01       Impact factor: 11.205

10.  Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain.

Authors:  M Hofer; S R Pagliusi; A Hohn; J Leibrock; Y A Barde
Journal:  EMBO J       Date:  1990-08       Impact factor: 11.598
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  2 in total

1.  Nerve growth factor depletion reduces collateral sprouting of cutaneous mechanoreceptive and tooth-pulp axons in ferrets.

Authors:  B Doubleday; P P Robinson
Journal:  J Physiol       Date:  1994-12-15       Impact factor: 5.182

2.  The effect of NGF depletion on the neurotropic influence exerted by the distal stump following nerve transection.

Authors:  B Doubleday; P P Robinson
Journal:  J Anat       Date:  1995-06       Impact factor: 2.610
  2 in total

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