Investigation of high salt intake in a Nepalese population with low blood pressure.

The relation between BP and the factors influencing an increase in BP with age were investigated in the inhabitants of two representative hilly (Kotyang: 206 men and 212 women) and suburban (Bhadrakali: 265 and 244) villages in Nepal. BP for both sexes was statistically significantly higher in Bhadrakali than in Kotyang. Neither hypertension nor elevation of BP with age for men and very few women (1.4%) with hypertension were observed in Kotyang, while 10.9% of men and 4.9% of women were found to be hypertensive in Bhadrakali. Average urinary Na excretion was 183-221 mEq/day in both villages. Urinary Na/K ratio, percentage body fat (%Fat), total protein, total cholesterol and serum Ca were statistically significantly higher in Bhadrakali than in Kotyang, and maximal oxygen uptake and serum Mg were higher in Kotyang. In spite of high salt consumption, there was no increase in BP with age in Kotyang's males, suggesting that the BP may be influenced by physical activity, fat-free mass and nutrient consumption in addition to the high sodium intake, and that extremely high physical activity and very low %Fat could serve to mute the influence of high sodium intake.