Literature DB >> 8508909

Localization of angiotensin AT1 receptors in the rat heart conduction system.

J M Saavedra1, M Viswanathan, K Shigematsu.   

Abstract

We characterized angiotensin II receptor subtypes in the conduction system of the rat heart using quantitative autoradiography. In both the sinoatrial and atrioventricular nodes, binding could be totally displaced by losartan, and was insensitive to PD 123177, indicating that angiotensin II receptors in the conduction system of the rat heart belong to the AT1 subtype. Angiotensin AT1 receptors could play a direct role in the regulation of the heart chronotropic properties.

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Year:  1993        PMID： 8508909     DOI： 10.1016/0014-2999(93)90150-g

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  4 in total

1.  Overexpression of angiotensin AT1 receptor transgene in the mouse myocardium produces a lethal phenotype associated with myocyte hyperplasia and heart block.

Authors:  L Hein; M E Stevens; G S Barsh; R E Pratt; B K Kobilka; V J Dzau
Journal:  Proc Natl Acad Sci U S A       Date:  1997-06-10       Impact factor: 11.205

2.  Type-1 angiotensin receptors are expressed and transported in motor and sensory axons of rat sciatic nerves.

Authors:  Hui Tang; Jaroslav Pavel; Juan M Saavedra; Stephen Brimijoin
Journal:  Neuropeptides       Date:  2009-02-23       Impact factor: 3.286

3.  Direct positive chronotropic effects of angiotensin II and angiotensin III in pithed rats and in rat isolated atria.

Authors:  Q Li; J Zhang; M Pfaffendorf; P A van Zwieten
Journal:  Br J Pharmacol       Date:  1996-08       Impact factor: 8.739

4.  Mechanisms of angiotensin II chronotropic effect in anaesthetized dogs.

Authors:  C Lambert
Journal:  Br J Pharmacol       Date:  1995-07       Impact factor: 8.739
  4 in total

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