| Literature DB >> 8508668 |
S A Matlin1, A Belenguer, V E Stacey, S Z Qian, Y Xu, J W Zhang, J K Sanders, S R Amor, C M Pearce.
Abstract
Extracts of the Chinese medicinal plant, Tripterygium wilfordii, cause reversible infertility in male animals. Sub-fractionation studies have now revealed that the plant extracts contain a number of compounds which are potent antifertility agents in male mammals, including the diterpenes triptolide and tripdiolide and an isomer of the latter. A triptolide, 12,13-chlorohydrin, which is a transformation product formed reversibly by interaction of triptolide with HCl, was also found to be active.Entities:
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Year: 1993 PMID： 8508668 DOI： 10.1016/0010-7824(93)90036-7
Source DB: PubMed Journal: Contraception ISSN： 0010-7824 Impact factor: 3.375