Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Expression of mRNA for the GATA-binding proteins in human eosinophils and basophils: potential role in gene transcription.

Literature DB >> 8507862

Expression of mRNA for the GATA-binding proteins in human eosinophils and basophils: potential role in gene transcription.

L I Zon¹, Y Yamaguchi, K Yee, E A Albee, A Kimura, J C Bennett, S H Orkin, S J Ackerman.

Abstract

The expression of the hematopoietic transcription factors GATA-1, GATA-2, and GATA-3 was studied in eosinophils and basophils. Eosinophils express mRNA for GATA-1, GATA-2, and GATA-3. Basophils express GATA-2 and GATA-3. Treatment of HL-60 eosinophilic sublines with either interleukin-5 or butyric acid increased the expression of GATA-1 mRNA concomitant with the expression of eosinophil-specific genes, whereas levels of GATA-2 mRNA remained relatively constant. The presence of mRNA for these proteins in eosinophils and basophils suggests that gene transcription in these lineages may be regulated by GATA-binding proteins.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 1993 PMID： 8507862

Source DB: PubMed Journal: Blood ISSN： 0006-4971 Impact factor: 22.113

Keyword Cloud
Cited

48 in total

Review 1. Molecular regulation of cytokine gene expression during the immune response.

Authors: J P Viola; A Rao
Journal: J Clin Immunol Date: 1999-03 Impact factor: 8.317

2. Dimeric RFX proteins contribute to the activity and lineage specificity of the interleukin-5 receptor alpha promoter through activation and repression domains.

Authors: A Iwama; J Pan; P Zhang; W Reith; B Mach; D G Tenen; Z Sun
Journal: Mol Cell Biol Date: 1999-06 Impact factor: 4.272

3. Potentiation of GATA-2 activity through interactions with the promyelocytic leukemia protein (PML) and the t(15;17)-generated PML-retinoic acid receptor alpha oncoprotein.

Authors: S Tsuzuki; M Towatari; H Saito; T Enver
Journal: Mol Cell Biol Date: 2000-09 Impact factor: 4.272

4. An upstream, DNase I hypersensitive region of the hematopoietic-expressed transcription factor GATA-1 gene confers developmental specificity in transgenic mice.

Authors: M A McDevitt; Y Fujiwara; R A Shivdasani; S H Orkin
Journal: Proc Natl Acad Sci U S A Date: 1997-07-22 Impact factor: 11.205

10. Distinct clones are associated with the development of transient myeloproliferative disorder and acute megakaryocytic leukemia in a patient with Down syndrome.

Authors: Hirokazu Kanegane; Sayaka Watanabe; Keiko Nomura; Gang Xu; Etsuro Ito; Toshio Miyawaki
Journal: Int J Hematol Date: 2007-10 Impact factor: 2.490

Expression of mRNA for the GATA-binding proteins in human eosinophils and basophils: potential role in gene transcription.

Review 1. Molecular regulation of cytokine gene expression during the immune response.

2. Dimeric RFX proteins contribute to the activity and lineage specificity of the interleukin-5 receptor alpha promoter through activation and repression domains.

3. Potentiation of GATA-2 activity through interactions with the promyelocytic leukemia protein (PML) and the t(15;17)-generated PML-retinoic acid receptor alpha oncoprotein.

4. An upstream, DNase I hypersensitive region of the hematopoietic-expressed transcription factor GATA-1 gene confers developmental specificity in transgenic mice.

5. Transcription factor-mediated lineage switching reveals plasticity in primary committed progenitor cells.

6. The role of transcription factors in the guidance of granulopoiesis.

Review 7. GATA transcription factors in hematologic disease.

8. GATA1 function, a paradigm for transcription factors in hematopoiesis.

9. The order of expression of transcription factors directs hierarchical specification of hematopoietic lineages.

10. Distinct clones are associated with the development of transient myeloproliferative disorder and acute megakaryocytic leukemia in a patient with Down syndrome.