Literature DB >> 8507200

Midkine is a mediator of retinoic acid induced neuronal differentiation of embryonal carcinoma cells.

M Michikawa1, R Y Xu, H Muramatsu, T Muramatsu, S U Kim.   

Abstract

Midkine (MK) is a novel growth factor and is the product of a retinoic acid responsive gene. When P19 murine embryonal carcinoma (EC) cells were exposed to MK, they differentiated into neurons, and the neuronal differentiation was accompanied by expression of choline acetyltransferase activity. Synthesis and release of MK in the EC cells treated with retinoic acid were shown by Western blot analysis, and rabbit anti-MK antibody attenuated the action of retinoic acid to induce the neuronal differentiation. These results indicate that MK is one of the mediators of retinoic acid action to induce the neuronal differentiation in EC cells.

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Year:  1993        PMID： 8507200     DOI： 10.1006/bbrc.1993.1559

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  5 in total

1.  Solution structure of midkine, a new heparin-binding growth factor.

Authors:  W Iwasaki; K Nagata; H Hatanaka; T Inui; T Kimura; T Muramatsu; K Yoshida; M Tasumi; F Inagaki
Journal:  EMBO J       Date:  1997-12-01       Impact factor: 11.598

2.  Midkine accumulated in nucleolus of HepG2 cells involved in rRNA transcription.

Authors:  Li-Cheng Dai; Jian-Zhong Shao; Li-Shan Min; Yong-Tao Xiao; Li-Xin Xiang; Zhi-Hong Ma
Journal:  World J Gastroenterol       Date:  2008-10-28       Impact factor: 5.742

3.  In vitro and in vivo suppression of hepatocellular carcinoma growth by midkine-antisense oligonucleotide-loaded nanoparticles.

Authors:  Li-Cheng Dai; Xing Yao; Xiang Wang; Shu-Qiong Niu; Lin-Fu Zhou; Fang-Fang Fu; Shui-Xin Yang; Jin-Liang Ping
Journal:  World J Gastroenterol       Date:  2009-04-28       Impact factor: 5.742

4.  Cortical gene expression in spinal cord injury and repair: insight into the functional complexity of the neural regeneration program.

Authors:  Fabian Kruse; Frank Bosse; Christina F Vogelaar; Nicole Brazda; Patrick Küry; Marcia Gasis; Hans W Müller
Journal:  Front Mol Neurosci       Date:  2011-09-29       Impact factor: 5.639

5.  A single intracoronary injection of midkine reduces ischemia/reperfusion injury in Swine hearts: a novel therapeutic approach for acute coronary syndrome.

Authors:  Hisaaki Ishiguro; Mitsuru Horiba; Hiroharu Takenaka; Arihiro Sumida; Tobias Opthof; Yuko S Ishiguro; Kenji Kadomatsu; Toyoaki Murohara; Itsuo Kodama
Journal:  Front Physiol       Date:  2011-06-23       Impact factor: 4.566
  5 in total

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